Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973758519> ?p ?o ?g. }
Showing items 1 to 48 of
48
with 100 items per page.
- W2973758519 endingPage "1188" @default.
- W2973758519 startingPage "1179" @default.
- W2973758519 abstract "Type 1 diabetes mellitus (DM1) leads to the dysfunctions of the male reproductive system, including an androgen deficiency and impaired spermatogenesis. However, in the conditions of DM1, the activity of the steroidogenesis system in the testes and the relationship between the impaired steroidogenesis and spermatogenesis and the metabolic and hormonal changes remain poorly understood. The aim of the work was to study the steroidogenesis and the spermatogenesis in male mice with the severe (sDM) and moderate (mDM) DM1 induced by subsequent streptozotocin treatment. The plasma levels of fasting glucose and insulin in the sDM and mDM groups of mice were 11.6±1.5 and 8.5±1.0 mM and 0.13±0.04 and 0.21±0.06 ng/mL, and were significantly different from those in control (5.1±0.4 mM and 0.43±0.08 ng/mL, P<0.05). In the sDM group, as compared to control, the plasma levels of leptin and testosterone were decreased significantly, and in the testes, the expression of genes encoding the transport protein StAR and the steroidogenic enzymes, such as the cytochromes P450scc and P450-17α and the dehydrogenase 3β-HSD and 17 β-HSD, was decreased on average by 30–40%. In the sDM group, the spermiogram analysis showed a decrease in the number of spermatozoa with forward rectilinear motion and an increase in the morphologically defective forms. In mice of the mDM group, these changes were less pronounced. Paradoxically, in the mDM group, the intratesticular progesterone and testosterone levels were reduced, while in the sDM group, despite an androgen deficiency, they did not differ from those in the control, which may be due to an impaired testosterone transport into the bloodstream in the conditions of a more severe form of DM1. Thus, the specific changes in steroidogenesis and spermatogenesis in male mice with DM1 of varying severity were studied, which must be considered when developing approaches to treat the reproductive dysfunctions associated with diabetic pathology." @default.
- W2973758519 created "2019-09-26" @default.
- W2973758519 creator A5003192535 @default.
- W2973758519 creator A5011257254 @default.
- W2973758519 creator A5032693120 @default.
- W2973758519 creator A5040151066 @default.
- W2973758519 creator A5042260127 @default.
- W2973758519 creator A5057127822 @default.
- W2973758519 creator A5067687796 @default.
- W2973758519 date "2019-01-01" @default.
- W2973758519 modified "2023-09-27" @default.
- W2973758519 title "Стероидогенез и сперматогенез у самцов мышей со стрептозотоциновым сахарным диабетом" @default.
- W2973758519 doi "https://doi.org/10.1134/s0869813919090115" @default.
- W2973758519 hasPublicationYear "2019" @default.
- W2973758519 type Work @default.
- W2973758519 sameAs 2973758519 @default.
- W2973758519 citedByCount "0" @default.
- W2973758519 crossrefType "journal-article" @default.
- W2973758519 hasAuthorship W2973758519A5003192535 @default.
- W2973758519 hasAuthorship W2973758519A5011257254 @default.
- W2973758519 hasAuthorship W2973758519A5032693120 @default.
- W2973758519 hasAuthorship W2973758519A5040151066 @default.
- W2973758519 hasAuthorship W2973758519A5042260127 @default.
- W2973758519 hasAuthorship W2973758519A5057127822 @default.
- W2973758519 hasAuthorship W2973758519A5067687796 @default.
- W2973758519 hasConcept C17744445 @default.
- W2973758519 hasConceptScore W2973758519C17744445 @default.
- W2973758519 hasIssue "9" @default.
- W2973758519 hasLocation W29737585191 @default.
- W2973758519 hasOpenAccess W2973758519 @default.
- W2973758519 hasPrimaryLocation W29737585191 @default.
- W2973758519 hasRelatedWork W11786335 @default.
- W2973758519 hasRelatedWork W13006181 @default.
- W2973758519 hasRelatedWork W19484413 @default.
- W2973758519 hasRelatedWork W19643091 @default.
- W2973758519 hasRelatedWork W20283368 @default.
- W2973758519 hasRelatedWork W25979448 @default.
- W2973758519 hasRelatedWork W26287046 @default.
- W2973758519 hasRelatedWork W26836251 @default.
- W2973758519 hasRelatedWork W29222237 @default.
- W2973758519 hasRelatedWork W7750287 @default.
- W2973758519 hasVolume "105" @default.
- W2973758519 isParatext "false" @default.
- W2973758519 isRetracted "false" @default.
- W2973758519 magId "2973758519" @default.
- W2973758519 workType "article" @default.