Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973765418> ?p ?o ?g. }
- W2973765418 abstract "Abstract Mainstay treatment for Plasmodium vivax malaria has long relied on chloroquine (CQ) against blood-stage parasites plus primaquine against dormant liver-stage forms (hypnozoites), however drug resistance confronts this regimen and threatens malaria control programs. Understanding the basis of P. vivax chloroquine resistance (CQR) will inform drug discovery and malaria control. Here we investigate the genetics of P. vivax CQR by a cross of parasites differing in drug response. Gametocytogenesis, mosquito infection, and progeny production are performed with mixed parasite populations in nonhuman primates, as methods for P. vivax cloning and in vitro cultivation remain unavailable. Linkage mapping of progeny surviving >15 mg/kg CQ identifies a 76 kb region in chromosome 1 including pvcrt , an ortholog of the Plasmodium falciparum CQR transporter gene. Transcriptional analysis supports upregulated pvcrt expression as a mechanism of CQR." @default.
- W2973765418 created "2019-09-26" @default.
- W2973765418 creator A5000295555 @default.
- W2973765418 creator A5002734044 @default.
- W2973765418 creator A5003426848 @default.
- W2973765418 creator A5003819823 @default.
- W2973765418 creator A5006398697 @default.
- W2973765418 creator A5014905876 @default.
- W2973765418 creator A5018491787 @default.
- W2973765418 creator A5023161333 @default.
- W2973765418 creator A5027916278 @default.
- W2973765418 creator A5029354918 @default.
- W2973765418 creator A5033979518 @default.
- W2973765418 creator A5034014450 @default.
- W2973765418 creator A5034623422 @default.
- W2973765418 creator A5035646331 @default.
- W2973765418 creator A5038420672 @default.
- W2973765418 creator A5038574644 @default.
- W2973765418 creator A5039590396 @default.
- W2973765418 creator A5041803228 @default.
- W2973765418 creator A5044942708 @default.
- W2973765418 creator A5045175926 @default.
- W2973765418 creator A5050108287 @default.
- W2973765418 creator A5050755743 @default.
- W2973765418 creator A5053078409 @default.
- W2973765418 creator A5053899510 @default.
- W2973765418 creator A5054709660 @default.
- W2973765418 creator A5057464085 @default.
- W2973765418 creator A5059624566 @default.
- W2973765418 creator A5063657802 @default.
- W2973765418 creator A5064602133 @default.
- W2973765418 creator A5067549205 @default.
- W2973765418 creator A5068547124 @default.
- W2973765418 creator A5071673766 @default.
- W2973765418 creator A5077697410 @default.
- W2973765418 creator A5086534599 @default.
- W2973765418 creator A5087910015 @default.
- W2973765418 creator A5089505099 @default.
- W2973765418 date "2019-09-20" @default.
- W2973765418 modified "2023-09-30" @default.
- W2973765418 title "Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross" @default.
- W2973765418 cites W1591979700 @default.
- W2973765418 cites W1825227406 @default.
- W2973765418 cites W1906493634 @default.
- W2973765418 cites W1919257374 @default.
- W2973765418 cites W1931922687 @default.
- W2973765418 cites W1966882987 @default.
- W2973765418 cites W1973953195 @default.
- W2973765418 cites W1973997241 @default.
- W2973765418 cites W1977784023 @default.
- W2973765418 cites W1981723999 @default.
- W2973765418 cites W1991334711 @default.
- W2973765418 cites W2007143886 @default.
- W2973765418 cites W2007629892 @default.
- W2973765418 cites W2015551715 @default.
- W2973765418 cites W2027678558 @default.
- W2973765418 cites W2031180216 @default.
- W2973765418 cites W2033985665 @default.
- W2973765418 cites W2043951056 @default.
- W2973765418 cites W2048317542 @default.
- W2973765418 cites W2050205342 @default.
- W2973765418 cites W2055008118 @default.
- W2973765418 cites W2055266017 @default.
- W2973765418 cites W2056485951 @default.
- W2973765418 cites W2064182323 @default.
- W2973765418 cites W2065879438 @default.
- W2973765418 cites W2069437402 @default.
- W2973765418 cites W2080956225 @default.
- W2973765418 cites W2088758272 @default.
- W2973765418 cites W2100419926 @default.
- W2973765418 cites W2102882733 @default.
- W2973765418 cites W2106376891 @default.
- W2973765418 cites W2107277218 @default.
- W2973765418 cites W2108234281 @default.
- W2973765418 cites W2108376610 @default.
- W2973765418 cites W2114418518 @default.
- W2973765418 cites W2119180969 @default.
- W2973765418 cites W2124952744 @default.
- W2973765418 cites W2125707752 @default.
- W2973765418 cites W2132107151 @default.
- W2973765418 cites W2132923209 @default.
- W2973765418 cites W2147515823 @default.
- W2973765418 cites W2149299310 @default.
- W2973765418 cites W2151383900 @default.
- W2973765418 cites W2154920950 @default.
- W2973765418 cites W2162928486 @default.
- W2973765418 cites W2168133698 @default.
- W2973765418 cites W2262556399 @default.
- W2973765418 cites W2267301389 @default.
- W2973765418 cites W2410250555 @default.
- W2973765418 cites W2462219738 @default.
- W2973765418 cites W2467177598 @default.
- W2973765418 cites W2473201955 @default.
- W2973765418 cites W2514285416 @default.
- W2973765418 cites W2742577290 @default.
- W2973765418 cites W2755424994 @default.
- W2973765418 cites W2787927001 @default.
- W2973765418 cites W2811182143 @default.
- W2973765418 cites W2913803367 @default.
- W2973765418 cites W2915054834 @default.