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- W2973768170 abstract "Abstract Background We aimed to evaluate the associations between calcium and various stages of colorectal carcinogenesis and whether these associations are modified by the calcium to magnesium (Ca:Mg) ratio. Methods We tested our hypotheses in the prostate lung, colorectal and ovarian cancer screening trial. Results Calcium intake did not show a dose–response association with incident adenoma of any size/stage ( P - trend = 0.17), but followed an inverse trend when restricted to synchronous/advanced adenoma cases ( P - trend = 0.05). This inverse trend was mainly in participants with Ca:Mg ratios between 1.7 and 2.5 ( P - trend = 0.05). No significant associations were observed for metachronous adenoma. Calcium intake was inversely associated with CRC ( P - trend = 0.03); the association was primarily present for distal CRC ( P - trend = 0.01). The inverse association between calcium and distal CRC was further modified by the Ca:Mg ratio ( P - interaction < 0.01); significant dose–response associations were found only in participants with a Ca:Mg ratio between 1.7 and 2.5 ( P - trend = 0.04). No associations for calcium were found in the Ca:Mg ratio above 2.5 or below 1.7. Conclusion Higher calcium intake may be related to reduced risks of incident advanced and/or synchronous adenoma and incident distal CRC among subjects with Ca:Mg intake ratios between 1.7 and 2.5." @default.
- W2973768170 created "2019-09-26" @default.
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- W2973768170 date "2019-09-23" @default.
- W2973768170 modified "2023-10-07" @default.
- W2973768170 title "Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial" @default.
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- W2973768170 doi "https://doi.org/10.1038/s41416-019-0579-2" @default.
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