FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973804954> ?p ?o ?g. }

• W2973804954 endingPage "259" @default.
• W2973804954 startingPage "240" @default.
• W2973804954 abstract "Abstract The functionality of long noncoding RNAs (lncRNAs) is disputed. In general, lncRNAs are under weak selective pressures, suggesting that the majority of lncRNAs may be nonfunctional. However, although some surveys showed negligible phenotypic effects upon lncRNA perturbation, key biological roles were demonstrated for individual lncRNAs. Most lncRNAs with proven functions were implicated in gene expression regulation, in pathways related to cellular pluripotency, differentiation, and organ morphogenesis, suggesting that functional lncRNAs may be more abundant in embryonic development, rather than in adult organs. To test this hypothesis, we perform a multidimensional comparative transcriptomics analysis, across five developmental time points (two embryonic stages, newborn, adult, and aged individuals), four organs (brain, kidney, liver, and testes), and three species (mouse, rat, and chicken). We find that, overwhelmingly, lncRNAs are preferentially expressed in adult and aged testes, consistent with the presence of permissive transcription during spermatogenesis. LncRNAs are often differentially expressed among developmental stages and are less abundant in embryos and newborns compared with adult individuals, in agreement with a requirement for tighter expression control and less tolerance for noisy transcription early in development. For differentially expressed lncRNAs, we find that the patterns of expression variation among developmental stages are generally conserved between mouse and rat. Moreover, lncRNAs expressed above noise levels in somatic organs and during development show higher evolutionary conservation, in particular, at their promoter regions. Thus, we show that functionally constrained lncRNA loci are enriched in developing organs, and we suggest that many of these loci may function in an RNA-independent manner." @default.
• W2973804954 created "2019-09-26" @default.
• W2973804954 creator A5012481314 @default.
• W2973804954 creator A5047484832 @default.
• W2973804954 date "2019-09-20" @default.
• W2973804954 modified "2023-10-18" @default.
• W2973804954 title "Comparative Transcriptomics Analyses across Species, Organs, and Developmental Stages Reveal Functionally Constrained lncRNAs" @default.
• W2973804954 cites W1602695373 @default.
• W2973804954 cites W1973445288 @default.
• W2973804954 cites W1975334494 @default.
• W2973804954 cites W1981301360 @default.
• W2973804954 cites W1982603712 @default.
• W2973804954 cites W1983275320 @default.
• W2973804954 cites W1999746344 @default.
• W2973804954 cites W2016515548 @default.
• W2973804954 cites W2021168471 @default.
• W2973804954 cites W2029868997 @default.
• W2973804954 cites W2029919331 @default.
• W2973804954 cites W2031896201 @default.
• W2973804954 cites W2047774280 @default.
• W2973804954 cites W2055043387 @default.
• W2973804954 cites W2056419701 @default.
• W2973804954 cites W2064975570 @default.
• W2973804954 cites W2088069070 @default.
• W2973804954 cites W2095903180 @default.
• W2973804954 cites W2101101443 @default.
• W2973804954 cites W2102120094 @default.
• W2973804954 cites W2102278945 @default.
• W2973804954 cites W2102818379 @default.
• W2973804954 cites W2104005232 @default.
• W2973804954 cites W2107959716 @default.
• W2973804954 cites W2112132489 @default.
• W2973804954 cites W2116236561 @default.
• W2973804954 cites W2121286812 @default.
• W2973804954 cites W2124560890 @default.
• W2973804954 cites W2128680767 @default.
• W2973804954 cites W2132053064 @default.
• W2973804954 cites W2134033103 @default.
• W2973804954 cites W2134625814 @default.
• W2973804954 cites W2138884188 @default.
• W2973804954 cites W2139658526 @default.
• W2973804954 cites W2140034535 @default.
• W2973804954 cites W2142678478 @default.
• W2973804954 cites W2142735201 @default.
• W2973804954 cites W2144137532 @default.
• W2973804954 cites W2145191876 @default.
• W2973804954 cites W2145931730 @default.
• W2973804954 cites W2152239989 @default.
• W2973804954 cites W2156880688 @default.
• W2973804954 cites W2157512257 @default.
• W2973804954 cites W2161901690 @default.
• W2973804954 cites W2162823258 @default.
• W2973804954 cites W2166251028 @default.
• W2973804954 cites W2167807908 @default.
• W2973804954 cites W2179438025 @default.
• W2973804954 cites W2263703262 @default.
• W2973804954 cites W2323326409 @default.
• W2973804954 cites W2339414115 @default.
• W2973804954 cites W2511664109 @default.
• W2973804954 cites W2514110482 @default.
• W2973804954 cites W2540381357 @default.
• W2973804954 cites W2546360008 @default.
• W2973804954 cites W2566949887 @default.
• W2973804954 cites W2765458541 @default.
• W2973804954 cites W2787788280 @default.
• W2973804954 cites W2797313452 @default.
• W2973804954 cites W2888403713 @default.
• W2973804954 cites W2888500336 @default.
• W2973804954 cites W2894687190 @default.
• W2973804954 cites W2898402099 @default.
• W2973804954 cites W2898603273 @default.
• W2973804954 cites W2903241977 @default.
• W2973804954 cites W2905158219 @default.
• W2973804954 cites W2909742725 @default.
• W2973804954 cites W2950464315 @default.
• W2973804954 cites W2952377671 @default.
• W2973804954 cites W2953483328 @default.
• W2973804954 cites W2954492537 @default.
• W2973804954 cites W4210702584 @default.
• W2973804954 cites W4237403594 @default.
• W2973804954 cites W4240605225 @default.
• W2973804954 doi "https://doi.org/10.1093/molbev/msz212" @default.
• W2973804954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6984365" @default.
• W2973804954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31539080" @default.
• W2973804954 hasPublicationYear "2019" @default.
• W2973804954 type Work @default.
• W2973804954 sameAs 2973804954 @default.
• W2973804954 citedByCount "26" @default.
• W2973804954 countsByYear W29738049542020 @default.
• W2973804954 countsByYear W29738049542021 @default.
• W2973804954 countsByYear W29738049542022 @default.
• W2973804954 countsByYear W29738049542023 @default.
• W2973804954 crossrefType "journal-article" @default.
• W2973804954 hasAuthorship W2973804954A5012481314 @default.
• W2973804954 hasAuthorship W2973804954A5047484832 @default.
• W2973804954 hasBestOaLocation W29738049541 @default.
• W2973804954 hasConcept C104317684 @default.
• W2973804954 hasConcept C127716648 @default.

• next