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• W2973837425 abstract "Traumatic brain injury (TBI) is a major public health concern affecting 2.8 million people per year in the United States, of whom about 1 million are children under 19 years old. Animal models of TBI have been developed and used in multiple ages of animals, but direct comparisons of adult and adolescent populations are rare. The current studies were undertaken to directly compare outcomes between adult and adolescent male mice, using a closed head, single-impact model of TBI. Six-week-old adolescent and 9-week-old adult male mice were subjected to mild-moderate TBI. Histological measures for neurodegeneration, gliosis, and microglial neuroinflammation, and behavioral tests of locomotion and memory were performed. Adolescent TBI mice have increased mortality (Χ2  = 20.72, p < 0.001) compared to adults. There is also evidence of hippocampal neurodegeneration in adolescents that is not present in adults. Hippocampal neurodegeneration correlates with histologic activation of microglia, but not with increased astrogliosis. Adults and adolescents have similar locomotion deficits after TBI that recover by 16 days postinjury. Adolescents have memory deficits as evidenced by impaired novel object recognition between 3-4 and 4-16 days postinjury (F1,26  = 5.23, p = 0.031) while adults do not. In conclusion, adults and adolescents within a close age range (6-9 weeks) respond to TBI differently. Adolescents are more severely affected by mortality, neurodegeneration, and inflammation in the hippocampus compared to adults. Adolescents, but not adults, have worse memory performance after TBI that lasts at least 16 days postinjury." @default.
• W2973837425 created "2019-09-26" @default.
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• W2973837425 date "2019-09-20" @default.
• W2973837425 modified "2023-10-17" @default.
• W2973837425 title "Greater neurodegeneration and behavioral deficits after single closed head traumatic brain injury in adolescent versus adult male mice" @default.
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• W2973837425 doi "https://doi.org/10.1002/jnr.24535" @default.
• W2973837425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6980517" @default.
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• W2973837425 hasPublicationYear "2019" @default.
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