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• W2973887603 abstract "Abstract Background PET radiopharmaceutical development and the implementation of a production method on a synthesis module is a complex and time-intensive task since new synthesis methods must be adapted to the confines of the synthesis platform in use. Commonly utilized single fluid bus architectures put multiple constraints on synthesis planning and execution, while conventional microfluidic solutions are limited by compatibility at the macro-to-micro interface . In this work we introduce the ISAR synthesis platform and custom-tailored fluid paths leveraging up to 70 individually addressable valves on a chip-based consumable. The ISAR synthesis platform replaces traditional stopcock valve manifolds with a fluidic chip that integrates all fluid paths (tubing) and valves into one consumable and enables channel routing without the single fluid bus constraint. ISAR can scale between the macro- (10 mL), meso- (0.5 mL) and micro- (≤0.05 mL) domain seamlessly, addressing the macro-to-micro interface challenge and enabling custom tailored fluid circuits for a given application. In this paper we demonstrate proof-of-concept by validating a single chip design to address the challenge of synthesizing multiple batches of [ 13 N]NH 3 for clinical use throughout the workday. Results ISAR was installed at an academic PET Center and used to manufacture [ 13 N]NH 3 in > 96% radiochemical yield. Up to 9 batches were manufactured with a single consumable chip having parallel paths without the need to open the hot-cell. Quality control testing confirmed the ISAR-based [ 13 N]NH 3 met existing clinical release specifications, and utility was demonstrated by imaging a rodent with [ 13 N]NH 3 produced on ISAR. Conclusions ISAR represents a new paradigm in radiopharmaceutical production. Through a new system architecture, ISAR integrates the principles of microfluidics with the standard volumes and consumables established in PET Centers all over the world. Proof-of-concept has been demonstrated through validation of a chip design for the synthesis of [ 13 N]NH 3 suitable for clinical use." @default.
• W2973887603 created "2019-09-26" @default.
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• W2973887603 date "2019-09-18" @default.
• W2973887603 modified "2023-09-27" @default.
• W2973887603 title "Development and implementation of ISAR, a new synthesis platform for radiopharmaceutical production" @default.
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• W2973887603 doi "https://doi.org/10.1186/s41181-019-0077-0" @default.
• W2973887603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6751239" @default.
• W2973887603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31659546" @default.
• W2973887603 hasPublicationYear "2019" @default.
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