Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973943950> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2973943950 endingPage "214" @default.
- W2973943950 startingPage "211" @default.
- W2973943950 abstract "Abstract Glioblastoma, an aggressive malign tumor of the brain, is one of the most shattering diagnoses due to its very poor prognosis and limited treatment options. These options mainly consist of surgical or radiation therapeutic removal of as much tumor mass as possible, which unfortunately is almost always incomplete. Even worse, chemotherapy is of little use, as the special setup of the brain′s vessels severely limits the transit into the parenchyma of elsewhere efficient cytostatica. This Blood-Brain-Barrier (BBB) is for quite some time the target of sophisticated and nano-particle based transport mechanisms, however it is reported, that a boost of permeability for most of the brain can be achieved based on moderate temperature increase. One means to locally and reversibly increase the brain′s temperature and thus potentially opening the BBB may be achieved by illuminating the skull with infrared laser light, thus causing punctual heating and heat diffusion into the cortex. In extension of the common laser light guiding by glass fibres, we use a micro-positioned simple optics to focus a 1470 nm laser beam of approximately 500 µm in diameter on the skull. The apparent opening of the BBB is evidenced by the localized spread of Evans Blue injected into the tail vein of said rat, binding to Albumin (64,6 kDa) in the body. This marker molecule is usually blocked from passing through the intact BBB, but under IR illumination for half a minute, it appeared in post mortem visible blobs. Temperature profiles and potential tissue damage are now under investigation by high speed thermal camera and post mortem histology." @default.
- W2973943950 created "2019-09-26" @default.
- W2973943950 creator A5003665614 @default.
- W2973943950 creator A5037391560 @default.
- W2973943950 creator A5068907033 @default.
- W2973943950 creator A5082404231 @default.
- W2973943950 date "2019-09-01" @default.
- W2973943950 modified "2023-10-14" @default.
- W2973943950 title "First Steps towards Localized Opening of the Blood-Brain-Barrier by IR Laser Illumination Through the Rodent Skull" @default.
- W2973943950 cites W2157036894 @default.
- W2973943950 doi "https://doi.org/10.1515/cdbme-2019-0054" @default.
- W2973943950 hasPublicationYear "2019" @default.
- W2973943950 type Work @default.
- W2973943950 sameAs 2973943950 @default.
- W2973943950 citedByCount "1" @default.
- W2973943950 countsByYear W29739439502023 @default.
- W2973943950 crossrefType "journal-article" @default.
- W2973943950 hasAuthorship W2973943950A5003665614 @default.
- W2973943950 hasAuthorship W2973943950A5037391560 @default.
- W2973943950 hasAuthorship W2973943950A5068907033 @default.
- W2973943950 hasAuthorship W2973943950A5082404231 @default.
- W2973943950 hasBestOaLocation W29739439501 @default.
- W2973943950 hasConcept C105702510 @default.
- W2973943950 hasConcept C120665830 @default.
- W2973943950 hasConcept C121332964 @default.
- W2973943950 hasConcept C12554922 @default.
- W2973943950 hasConcept C126322002 @default.
- W2973943950 hasConcept C136229726 @default.
- W2973943950 hasConcept C142724271 @default.
- W2973943950 hasConcept C150903083 @default.
- W2973943950 hasConcept C169760540 @default.
- W2973943950 hasConcept C185592680 @default.
- W2973943950 hasConcept C192562407 @default.
- W2973943950 hasConcept C196822366 @default.
- W2973943950 hasConcept C207001950 @default.
- W2973943950 hasConcept C2777649898 @default.
- W2973943950 hasConcept C2778402981 @default.
- W2973943950 hasConcept C2779130545 @default.
- W2973943950 hasConcept C2779300802 @default.
- W2973943950 hasConcept C2779540182 @default.
- W2973943950 hasConcept C3017562151 @default.
- W2973943950 hasConcept C520434653 @default.
- W2973943950 hasConcept C529278444 @default.
- W2973943950 hasConcept C71924100 @default.
- W2973943950 hasConcept C86803240 @default.
- W2973943950 hasConceptScore W2973943950C105702510 @default.
- W2973943950 hasConceptScore W2973943950C120665830 @default.
- W2973943950 hasConceptScore W2973943950C121332964 @default.
- W2973943950 hasConceptScore W2973943950C12554922 @default.
- W2973943950 hasConceptScore W2973943950C126322002 @default.
- W2973943950 hasConceptScore W2973943950C136229726 @default.
- W2973943950 hasConceptScore W2973943950C142724271 @default.
- W2973943950 hasConceptScore W2973943950C150903083 @default.
- W2973943950 hasConceptScore W2973943950C169760540 @default.
- W2973943950 hasConceptScore W2973943950C185592680 @default.
- W2973943950 hasConceptScore W2973943950C192562407 @default.
- W2973943950 hasConceptScore W2973943950C196822366 @default.
- W2973943950 hasConceptScore W2973943950C207001950 @default.
- W2973943950 hasConceptScore W2973943950C2777649898 @default.
- W2973943950 hasConceptScore W2973943950C2778402981 @default.
- W2973943950 hasConceptScore W2973943950C2779130545 @default.
- W2973943950 hasConceptScore W2973943950C2779300802 @default.
- W2973943950 hasConceptScore W2973943950C2779540182 @default.
- W2973943950 hasConceptScore W2973943950C3017562151 @default.
- W2973943950 hasConceptScore W2973943950C520434653 @default.
- W2973943950 hasConceptScore W2973943950C529278444 @default.
- W2973943950 hasConceptScore W2973943950C71924100 @default.
- W2973943950 hasConceptScore W2973943950C86803240 @default.
- W2973943950 hasIssue "1" @default.
- W2973943950 hasLocation W29739439501 @default.
- W2973943950 hasLocation W29739439502 @default.
- W2973943950 hasOpenAccess W2973943950 @default.
- W2973943950 hasPrimaryLocation W29739439501 @default.
- W2973943950 hasRelatedWork W1853951843 @default.
- W2973943950 hasRelatedWork W1998620774 @default.
- W2973943950 hasRelatedWork W2040480145 @default.
- W2973943950 hasRelatedWork W2043922378 @default.
- W2973943950 hasRelatedWork W2046342806 @default.
- W2973943950 hasRelatedWork W2047841272 @default.
- W2973943950 hasRelatedWork W2124618539 @default.
- W2973943950 hasRelatedWork W2138291619 @default.
- W2973943950 hasRelatedWork W2416543278 @default.
- W2973943950 hasRelatedWork W2969672695 @default.
- W2973943950 hasVolume "5" @default.
- W2973943950 isParatext "false" @default.
- W2973943950 isRetracted "false" @default.
- W2973943950 magId "2973943950" @default.
- W2973943950 workType "article" @default.