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- W2973968733 endingPage "109408" @default.
- W2973968733 startingPage "109408" @default.
- W2973968733 abstract "Serotonin, which also named as 5-hydroxytryptamine (5-HT), is a neurotransmitter, which plays significant roles in a wide range of physiological and pathological processes. Depression is a complex disease that involves numerous factors, increasing evidences have showed that the level of 5-HT was lower in depressed patients and the administration of some selective serotonin re-uptake inhibitors exhibited antidepressant effects. The 5-HT1A receptor is a key protein in the brain serotonin system, modulating the release of 5-HT and other neurotransmitters. Behavioral and molecular biological studies have demonstrated that the differences of 5-HT1A receptor regulation was connected with depression and the responses to antidepressants. In this review, the authors will introduce the structure and function of 5-HT1A receptor and summarize some antidepressants targeting 5-HT1A receptor, including 5-HT1A receptor agonists and antagonists in a clinic, active ingredients of traditional Chinese medicine. And we found the major of drugs by targeting 5-HT1A receptor on the market or in clinical trials mostly have the similar functional groups, such as piperazine, piperidine, and pyrimidine. There are also some literatures found that these functional groups may be the site produce activity. So, we hope that it may provide basis and references for the research of the clinical drugs for depression." @default.
- W2973968733 created "2019-09-26" @default.
- W2973968733 creator A5002430497 @default.
- W2973968733 creator A5021095828 @default.
- W2973968733 creator A5036025171 @default.
- W2973968733 creator A5060470951 @default.
- W2973968733 creator A5065556373 @default.
- W2973968733 creator A5083553501 @default.
- W2973968733 date "2019-12-01" @default.
- W2973968733 modified "2023-10-16" @default.
- W2973968733 title "Review of antidepressants in clinic and active ingredients of traditional Chinese medicine targeting 5-HT1A receptors" @default.
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