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- W2974112935 abstract "OBJECTIVE:--To describe secondary failure of initial metformin therapy in patients who achieved initial HbA[subscript 1c] (A1C) 8.0% after at least 6 months on metformin. RESULTS:--The best A1C achieved within 1 year of metformin initiation was the most powerful predictor of avoiding secondary failure. Approximately 50% of subjects whose best A1C was 7-7.9% added/switched antihyperglycemic drugs within 36 months, whereas it took >60 months for those in the 6-6.9% A1C category to reach a 50% failure rate. Those who achieved an A1C 8% within 24 months. Only [approximately]25% of subjects in the 6-6.9% category failed by 48 months, and >80% of subjects in the <6% category remained below 8% through 60 months. CONCLUSIONS:--Whether defined by adding/switching to another drug or by reaching an A1C of 8%, secondary failure is inversely associated with the reduction of A1C achieved within the 1st year of metformin monotherapy." @default.
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- W2974112935 date "2006-01-01" @default.
- W2974112935 modified "2023-09-23" @default.
- W2974112935 title "Treatment Escalation and Rise in HbA[subscript 1c] Following Successful Initial Metformin Therapy" @default.
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