FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2974124960> ?p ?o ?g. }

• W2974124960 abstract "Abstract Supplementation with the NAD + precursor nicotinamide riboside (NR) ameliorates and prevents a broad array of metabolic and aging disorders in mice. However, little is known about the physiological role of endogenous NR metabolism. We have previously shown that NR kinase 1 (NRK1) is rate-limiting and essential for NR-induced NAD + synthesis in hepatic cells. To understand the relevance of hepatic NR metabolism, we generated whole body and liver-specific NRK1 knockout mice. Here, we show that NRK1 deficiency leads to decreased gluconeogenic potential and impaired mitochondrial function. Upon high-fat feeding, NRK1 deficient mice develop glucose intolerance, insulin resistance and hepatosteatosis. Furthermore, they are more susceptible to diet-induced liver DNA damage, due to compromised PARP1 activity. Our results demonstrate that endogenous NR metabolism is critical to sustain hepatic NAD + levels and hinder diet-induced metabolic damage, highlighting the relevance of NRK1 as a therapeutic target for metabolic disorders." @default.
• W2974124960 created "2019-09-26" @default.
• W2974124960 creator A5011545241 @default.
• W2974124960 creator A5014047125 @default.
• W2974124960 creator A5015855199 @default.
• W2974124960 creator A5018627954 @default.
• W2974124960 creator A5021806244 @default.
• W2974124960 creator A5034921071 @default.
• W2974124960 creator A5046672994 @default.
• W2974124960 creator A5049020749 @default.
• W2974124960 creator A5056759605 @default.
• W2974124960 creator A5059021774 @default.
• W2974124960 creator A5071609094 @default.
• W2974124960 creator A5085996021 @default.
• W2974124960 creator A5089333088 @default.
• W2974124960 date "2019-09-20" @default.
• W2974124960 modified "2023-10-06" @default.
• W2974124960 title "Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage" @default.
• W2974124960 cites W1519310661 @default.
• W2974124960 cites W1523158326 @default.
• W2974124960 cites W1665938856 @default.
• W2974124960 cites W1910071664 @default.
• W2974124960 cites W1959721425 @default.
• W2974124960 cites W1974961331 @default.
• W2974124960 cites W1975344770 @default.
• W2974124960 cites W1994421049 @default.
• W2974124960 cites W2012043504 @default.
• W2974124960 cites W2016294119 @default.
• W2974124960 cites W2030392188 @default.
• W2974124960 cites W2038011036 @default.
• W2974124960 cites W2040625305 @default.
• W2974124960 cites W2055969761 @default.
• W2974124960 cites W2082393205 @default.
• W2974124960 cites W2090442368 @default.
• W2974124960 cites W2132438126 @default.
• W2974124960 cites W2147182901 @default.
• W2974124960 cites W2157296254 @default.
• W2974124960 cites W2159100311 @default.
• W2974124960 cites W2167665292 @default.
• W2974124960 cites W2171748049 @default.
• W2974124960 cites W2236926495 @default.
• W2974124960 cites W2237292223 @default.
• W2974124960 cites W2239653845 @default.
• W2974124960 cites W2400466055 @default.
• W2974124960 cites W2465287431 @default.
• W2974124960 cites W2499764253 @default.
• W2974124960 cites W2521759723 @default.
• W2974124960 cites W2530753724 @default.
• W2974124960 cites W2531264048 @default.
• W2974124960 cites W2531686927 @default.
• W2974124960 cites W2540412673 @default.
• W2974124960 cites W2547963687 @default.
• W2974124960 cites W2580092051 @default.
• W2974124960 cites W2588342194 @default.
• W2974124960 cites W2619938137 @default.
• W2974124960 cites W2752428556 @default.
• W2974124960 cites W2774690079 @default.
• W2974124960 cites W2774778331 @default.
• W2974124960 cites W2775008495 @default.
• W2974124960 cites W2792941608 @default.
• W2974124960 cites W2805234895 @default.
• W2974124960 doi "https://doi.org/10.1038/s41467-019-12262-x" @default.
• W2974124960 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6754455" @default.
• W2974124960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31541116" @default.
• W2974124960 hasPublicationYear "2019" @default.
• W2974124960 type Work @default.
• W2974124960 sameAs 2974124960 @default.
• W2974124960 citedByCount "28" @default.
• W2974124960 countsByYear W29741249602020 @default.
• W2974124960 countsByYear W29741249602021 @default.
• W2974124960 countsByYear W29741249602022 @default.
• W2974124960 countsByYear W29741249602023 @default.
• W2974124960 crossrefType "journal-article" @default.
• W2974124960 hasAuthorship W2974124960A5011545241 @default.
• W2974124960 hasAuthorship W2974124960A5014047125 @default.
• W2974124960 hasAuthorship W2974124960A5015855199 @default.
• W2974124960 hasAuthorship W2974124960A5018627954 @default.
• W2974124960 hasAuthorship W2974124960A5021806244 @default.
• W2974124960 hasAuthorship W2974124960A5034921071 @default.
• W2974124960 hasAuthorship W2974124960A5046672994 @default.
• W2974124960 hasAuthorship W2974124960A5049020749 @default.
• W2974124960 hasAuthorship W2974124960A5056759605 @default.
• W2974124960 hasAuthorship W2974124960A5059021774 @default.
• W2974124960 hasAuthorship W2974124960A5071609094 @default.
• W2974124960 hasAuthorship W2974124960A5085996021 @default.
• W2974124960 hasAuthorship W2974124960A5089333088 @default.
• W2974124960 hasBestOaLocation W29741249601 @default.
• W2974124960 hasConcept C126322002 @default.
• W2974124960 hasConcept C134018914 @default.
• W2974124960 hasConcept C16613235 @default.
• W2974124960 hasConcept C170493617 @default.
• W2974124960 hasConcept C181199279 @default.
• W2974124960 hasConcept C182704531 @default.
• W2974124960 hasConcept C182979987 @default.
• W2974124960 hasConcept C20251656 @default.
• W2974124960 hasConcept C2776901170 @default.
• W2974124960 hasConcept C2777391703 @default.
• W2974124960 hasConcept C2778480876 @default.
• W2974124960 hasConcept C2779728014 @default.
• W2974124960 hasConcept C28859421 @default.

• next