Matches in SemOpenAlex for { <https://semopenalex.org/work/W2974127513> ?p ?o ?g. }
- W2974127513 endingPage "200" @default.
- W2974127513 startingPage "188" @default.
- W2974127513 abstract "Ion channels are progressively emerging as a novel class of membrane proteins expressed in several types of human cancers and regulating the different aspects of cancer cell behavior. The metabolism of cancer cells, usually composed by a variable proportion of respiration, glycolysis, and glutaminolysis, leads to the excessive production of acidic metabolic products. The presence of these acidic metabolites inside the cells results in intracellular acidosis, and hinders survival and proliferation. For this reason, tumor cells activate mechanisms of pH control that produce a constitutive increase in intracellular pH (pHi) that is more acidic than the extracellular pH (pHe). This condition forms a perfect microenvironment for metastatic progression and may be permissive for some of the acquired characteristics of tumors. Recent analyses have revealed complex interconnections between oncogenic activation, ion channels, hypoxia signaling and metabolic pathways that are dysregulated in cancer. Here, we summarize the molecular mechanisms of the Warburg effect and hypoxia and their association. Moreover, we discuss the recent findings concerning the involvement of ion channels in various aspects of the Warburg effect and hypoxia, focusing on the role of Na+ and K+ channels in hypoxic and metabolic reprogramming in cancer." @default.
- W2974127513 created "2019-09-26" @default.
- W2974127513 creator A5006863555 @default.
- W2974127513 creator A5032049265 @default.
- W2974127513 creator A5033879297 @default.
- W2974127513 creator A5078954350 @default.
- W2974127513 date "2019-09-01" @default.
- W2974127513 modified "2023-10-01" @default.
- W2974127513 title "Potassium and Sodium Channels and the Warburg Effect: Biophysical Regulation of Cancer Metabolism" @default.
- W2974127513 cites W1493048246 @default.
- W2974127513 cites W1526980804 @default.
- W2974127513 cites W1541248931 @default.
- W2974127513 cites W1541296013 @default.
- W2974127513 cites W1573153072 @default.
- W2974127513 cites W1598178857 @default.
- W2974127513 cites W1601563281 @default.
- W2974127513 cites W1749022239 @default.
- W2974127513 cites W1883655199 @default.
- W2974127513 cites W1936449500 @default.
- W2974127513 cites W1947050531 @default.
- W2974127513 cites W1963923169 @default.
- W2974127513 cites W1963989251 @default.
- W2974127513 cites W1964961135 @default.
- W2974127513 cites W1970982176 @default.
- W2974127513 cites W1974205751 @default.
- W2974127513 cites W1978576661 @default.
- W2974127513 cites W1979770213 @default.
- W2974127513 cites W1980255492 @default.
- W2974127513 cites W1981487137 @default.
- W2974127513 cites W1983539529 @default.
- W2974127513 cites W1986948721 @default.
- W2974127513 cites W1992562665 @default.
- W2974127513 cites W1995444593 @default.
- W2974127513 cites W1999204839 @default.
- W2974127513 cites W2000976163 @default.
- W2974127513 cites W2001409949 @default.
- W2974127513 cites W2003046273 @default.
- W2974127513 cites W2003636213 @default.
- W2974127513 cites W2008480221 @default.
- W2974127513 cites W2010855741 @default.
- W2974127513 cites W2011912935 @default.
- W2974127513 cites W2015202978 @default.
- W2974127513 cites W2015207840 @default.
- W2974127513 cites W2016281393 @default.
- W2974127513 cites W2017035524 @default.
- W2974127513 cites W2018971639 @default.
- W2974127513 cites W2020699417 @default.
- W2974127513 cites W2022899908 @default.
- W2974127513 cites W2023243932 @default.
- W2974127513 cites W2027705428 @default.
- W2974127513 cites W2028268047 @default.
- W2974127513 cites W2032745109 @default.
- W2974127513 cites W2032855201 @default.
- W2974127513 cites W2033958147 @default.
- W2974127513 cites W2034586537 @default.
- W2974127513 cites W2036085963 @default.
- W2974127513 cites W2037547464 @default.
- W2974127513 cites W2038074574 @default.
- W2974127513 cites W2039558597 @default.
- W2974127513 cites W2040153309 @default.
- W2974127513 cites W2040235797 @default.
- W2974127513 cites W2041550182 @default.
- W2974127513 cites W2044495359 @default.
- W2974127513 cites W2046100445 @default.
- W2974127513 cites W2046795310 @default.
- W2974127513 cites W2047425323 @default.
- W2974127513 cites W2048216460 @default.
- W2974127513 cites W2049570498 @default.
- W2974127513 cites W2051292461 @default.
- W2974127513 cites W2052246066 @default.
- W2974127513 cites W2054205644 @default.
- W2974127513 cites W2056412577 @default.
- W2974127513 cites W2059949409 @default.
- W2974127513 cites W2062608680 @default.
- W2974127513 cites W2062938999 @default.
- W2974127513 cites W2064380858 @default.
- W2974127513 cites W2064608326 @default.
- W2974127513 cites W2066379425 @default.
- W2974127513 cites W2067213531 @default.
- W2974127513 cites W2068200390 @default.
- W2974127513 cites W2069269337 @default.
- W2974127513 cites W2069453842 @default.
- W2974127513 cites W2072451938 @default.
- W2974127513 cites W2072939418 @default.
- W2974127513 cites W2076715911 @default.
- W2974127513 cites W2080948706 @default.
- W2974127513 cites W2080971278 @default.
- W2974127513 cites W2083839003 @default.
- W2974127513 cites W2083913805 @default.
- W2974127513 cites W2085609942 @default.
- W2974127513 cites W2086111396 @default.
- W2974127513 cites W2086544742 @default.
- W2974127513 cites W2091102347 @default.
- W2974127513 cites W2091739490 @default.
- W2974127513 cites W2093170555 @default.
- W2974127513 cites W2095987251 @default.
- W2974127513 cites W2097259163 @default.
- W2974127513 cites W2103509505 @default.