FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2974140064> ?p ?o ?g. }

• W2974140064 endingPage "2272" @default.
• W2974140064 startingPage "2261" @default.
• W2974140064 abstract "Objective: Genome-wide association studies identified novel loci in PLPP3 (phospholipid phosphatase 3) that associate with coronary artery disease risk independently of traditional risk factors. PLPP3 encodes LPP3 (lipid phosphate phosphatase 3), a cell-surface enzyme that can regulate the availability of bioactive lysophopsholipids including lysophosphatidic acid (LPA). The protective allele of PLPP3 increases LPP3 expression during cell exposure to oxidized lipids, however, the role of LPP3 in atherosclerosis remains unclear. Approach and Results: In this study, we sought to validate LPP3 as a determinate of the development of atherosclerosis. In experimental models of atherosclerosis, LPP3 is upregulated and co-localizes with endothelial, smooth muscle cell, and CD68-positive cell markers. Global post-natal reductions in Plpp3 expression in mice substantially increase atherosclerosis, plaque-associated LPA, and inflammation. Although LPP3 expression increases during ox-LDL (oxidized low-density lipoprotein)-induced phenotypic modulation of bone marrow-derived macrophages, myeloid Plpp3 does not appear to regulate lesion formation. Rather, smooth muscle cell LPP3 expression is a critical regulator of atherosclerosis and LPA content in lesions. Moreover, mice with inherited deficiency in LPA receptor signaling are protected from experimental atherosclerosis. Conclusions: Our results identify a novel lipid signaling pathway that regulates inflammation in the context of atherosclerosis and is not related to traditional risk factors. Pharmacological targeting of bioactive LPP3 substrates, including LPA, may offer an orthogonal approach to lipid-lowering drugs for mitigation of coronary artery disease risk." @default.
• W2974140064 created "2019-09-26" @default.
• W2974140064 creator A5010812501 @default.
• W2974140064 creator A5038704186 @default.
• W2974140064 creator A5047517811 @default.
• W2974140064 creator A5052240542 @default.
• W2974140064 creator A5060651805 @default.
• W2974140064 creator A5060684279 @default.
• W2974140064 creator A5063861589 @default.
• W2974140064 creator A5069878413 @default.
• W2974140064 creator A5085091216 @default.
• W2974140064 creator A5090934719 @default.
• W2974140064 date "2019-11-01" @default.
• W2974140064 modified "2023-10-02" @default.
• W2974140064 title "Coronary Artery Disease Risk-Associated <i>Plpp3</i> Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis" @default.
• W2974140064 cites W1593707570 @default.
• W2974140064 cites W2012489652 @default.
• W2974140064 cites W2028274691 @default.
• W2974140064 cites W2028581975 @default.
• W2974140064 cites W2042725827 @default.
• W2974140064 cites W2048234788 @default.
• W2974140064 cites W2052338745 @default.
• W2974140064 cites W2089053666 @default.
• W2974140064 cites W2092205926 @default.
• W2974140064 cites W2092430017 @default.
• W2974140064 cites W2112848098 @default.
• W2974140064 cites W2121323318 @default.
• W2974140064 cites W2124900560 @default.
• W2974140064 cites W2125558267 @default.
• W2974140064 cites W2132202643 @default.
• W2974140064 cites W2137640482 @default.
• W2974140064 cites W2137940220 @default.
• W2974140064 cites W2138463356 @default.
• W2974140064 cites W2149557213 @default.
• W2974140064 cites W2160870763 @default.
• W2974140064 cites W2167409766 @default.
• W2974140064 cites W2169413839 @default.
• W2974140064 cites W2274924551 @default.
• W2974140064 cites W2344421431 @default.
• W2974140064 cites W2526157234 @default.
• W2974140064 cites W2553476028 @default.
• W2974140064 cites W2569940802 @default.
• W2974140064 cites W2640824658 @default.
• W2974140064 cites W2737249697 @default.
• W2974140064 cites W2741422107 @default.
• W2974140064 cites W2916918312 @default.
• W2974140064 cites W791380669 @default.
• W2974140064 doi "https://doi.org/10.1161/atvbaha.119.313056" @default.
• W2974140064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6812632" @default.
• W2974140064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31533471" @default.
• W2974140064 hasPublicationYear "2019" @default.
• W2974140064 type Work @default.
• W2974140064 sameAs 2974140064 @default.
• W2974140064 citedByCount "22" @default.
• W2974140064 countsByYear W29741400642020 @default.
• W2974140064 countsByYear W29741400642021 @default.
• W2974140064 countsByYear W29741400642022 @default.
• W2974140064 countsByYear W29741400642023 @default.
• W2974140064 crossrefType "journal-article" @default.
• W2974140064 hasAuthorship W2974140064A5010812501 @default.
• W2974140064 hasAuthorship W2974140064A5038704186 @default.
• W2974140064 hasAuthorship W2974140064A5047517811 @default.
• W2974140064 hasAuthorship W2974140064A5052240542 @default.
• W2974140064 hasAuthorship W2974140064A5060651805 @default.
• W2974140064 hasAuthorship W2974140064A5060684279 @default.
• W2974140064 hasAuthorship W2974140064A5063861589 @default.
• W2974140064 hasAuthorship W2974140064A5069878413 @default.
• W2974140064 hasAuthorship W2974140064A5085091216 @default.
• W2974140064 hasAuthorship W2974140064A5090934719 @default.
• W2974140064 hasBestOaLocation W29741400641 @default.
• W2974140064 hasConcept C126322002 @default.
• W2974140064 hasConcept C134018914 @default.
• W2974140064 hasConcept C170493617 @default.
• W2974140064 hasConcept C2776393769 @default.
• W2974140064 hasConcept C2776661833 @default.
• W2974140064 hasConcept C2776914184 @default.
• W2974140064 hasConcept C2777895019 @default.
• W2974140064 hasConcept C2778163477 @default.
• W2974140064 hasConcept C2778213512 @default.
• W2974140064 hasConcept C2780072125 @default.
• W2974140064 hasConcept C2991716557 @default.
• W2974140064 hasConcept C502942594 @default.
• W2974140064 hasConcept C71924100 @default.
• W2974140064 hasConcept C86803240 @default.
• W2974140064 hasConcept C95444343 @default.
• W2974140064 hasConceptScore W2974140064C126322002 @default.
• W2974140064 hasConceptScore W2974140064C134018914 @default.
• W2974140064 hasConceptScore W2974140064C170493617 @default.
• W2974140064 hasConceptScore W2974140064C2776393769 @default.
• W2974140064 hasConceptScore W2974140064C2776661833 @default.
• W2974140064 hasConceptScore W2974140064C2776914184 @default.
• W2974140064 hasConceptScore W2974140064C2777895019 @default.
• W2974140064 hasConceptScore W2974140064C2778163477 @default.
• W2974140064 hasConceptScore W2974140064C2778213512 @default.
• W2974140064 hasConceptScore W2974140064C2780072125 @default.
• W2974140064 hasConceptScore W2974140064C2991716557 @default.
• W2974140064 hasConceptScore W2974140064C502942594 @default.
• W2974140064 hasConceptScore W2974140064C71924100 @default.

• next