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- W2974176670 abstract "Some 1-((4-methylpiperazin-1yl)methyl)-1H-benzo[d]imidazole & 1-((4-phenylpiperazin-1yl)methyl)-1H-benzo[d]imidazole derivatives were synthesized through reaction of 1-substituted piperazines with different benzimidazole derivatives in methanol yielded the corresponding mannich bases (42-a to 42-i). All the synthesized compounds were elucidated by IR, 1H NMR and MASS spectroscopy. They were tested for anti-inflammatory activity using in-vivo (Carrageenan- induced rat paw edema model) method at a dose of 50mg/kg. result showed that compounds 42-c, 42-d and 42-h were found to be most potent in series.
 Keywords: 1,4-disubstituted Piperazine, Anti-inflammatory, Mannich Base." @default.
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- W2974176670 date "2019-08-15" @default.
- W2974176670 modified "2023-10-18" @default.
- W2974176670 title "Synthesis and Biological Evaluation of Some Piperazine Derivatives as Anti-Inflammatory Agents" @default.
- W2974176670 doi "https://doi.org/10.22270/jddt.v9i4-s.3327" @default.
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