Matches in SemOpenAlex for { <https://semopenalex.org/work/W2974241014> ?p ?o ?g. }
- W2974241014 endingPage "4674" @default.
- W2974241014 startingPage "4674" @default.
- W2974241014 abstract "In a previous proteomic study, we identified the neurosecretory protein VGF (VGF) as a potential biomarker for dementia with Lewy bodies (DLB). Here, we extended the study of VGF by comparing levels in cerebrospinal fluid (CSF) from 44 DLB patients, 20 Alzheimer’s disease (AD) patients, and 22 cognitively normal controls selected from the Amsterdam Dementia Cohort. CSF was analyzed using two orthogonal analytical methods: (1) In-house-developed quantitative ELISA and (2) selected reaction monitoring (SRM). We further addressed associations of VGF with other CSF biomarkers and cognition. VGF levels were lower in CSF from patients with DLB compared to either AD patients or controls. VGF was positively correlated with CSF tau and α-synuclein (0.55 < r < 0.75), but not with Aβ1-42. In DLB patients, low VGF levels were related to a more advanced cognitive decline at time of first presentation, whereas high levels of VGF were associated with steeper subsequent longitudinal cognitive decline. Hence, CSF VGF levels were lower in DLB compared to both AD and controls across different analytical methods. The strong associations with cognitive decline further points out VGF as a possible disease stage or prognostic marker for DLB." @default.
- W2974241014 created "2019-09-26" @default.
- W2974241014 creator A5020310949 @default.
- W2974241014 creator A5031293890 @default.
- W2974241014 creator A5038926287 @default.
- W2974241014 creator A5042986203 @default.
- W2974241014 creator A5046728515 @default.
- W2974241014 creator A5050058929 @default.
- W2974241014 creator A5057441631 @default.
- W2974241014 creator A5062002935 @default.
- W2974241014 creator A5071308068 @default.
- W2974241014 creator A5075394738 @default.
- W2974241014 creator A5089506479 @default.
- W2974241014 date "2019-09-20" @default.
- W2974241014 modified "2023-10-18" @default.
- W2974241014 title "VGF Peptides in Cerebrospinal Fluid of Patients with Dementia with Lewy Bodies" @default.
- W2974241014 cites W1499425429 @default.
- W2974241014 cites W1523782066 @default.
- W2974241014 cites W1527671059 @default.
- W2974241014 cites W1574604144 @default.
- W2974241014 cites W1577433680 @default.
- W2974241014 cites W1968352263 @default.
- W2974241014 cites W1981322456 @default.
- W2974241014 cites W1995487819 @default.
- W2974241014 cites W1999527871 @default.
- W2974241014 cites W2001058095 @default.
- W2974241014 cites W2027880941 @default.
- W2974241014 cites W2033572099 @default.
- W2974241014 cites W2033827101 @default.
- W2974241014 cites W2047101604 @default.
- W2974241014 cites W2052453119 @default.
- W2974241014 cites W2060631637 @default.
- W2974241014 cites W2062410112 @default.
- W2974241014 cites W2073678037 @default.
- W2974241014 cites W2079370736 @default.
- W2974241014 cites W2079688969 @default.
- W2974241014 cites W2081730310 @default.
- W2974241014 cites W2084139289 @default.
- W2974241014 cites W2090865245 @default.
- W2974241014 cites W2094479119 @default.
- W2974241014 cites W2096936673 @default.
- W2974241014 cites W2115713105 @default.
- W2974241014 cites W2117822586 @default.
- W2974241014 cites W2123104849 @default.
- W2974241014 cites W2130045340 @default.
- W2974241014 cites W2131897453 @default.
- W2974241014 cites W2138685200 @default.
- W2974241014 cites W2145294211 @default.
- W2974241014 cites W2149370276 @default.
- W2974241014 cites W2156326104 @default.
- W2974241014 cites W2250240315 @default.
- W2974241014 cites W2406510679 @default.
- W2974241014 cites W2521150622 @default.
- W2974241014 cites W2530233676 @default.
- W2974241014 cites W2621239131 @default.
- W2974241014 cites W2623521763 @default.
- W2974241014 cites W2739934261 @default.
- W2974241014 cites W2743633402 @default.
- W2974241014 cites W2744722702 @default.
- W2974241014 cites W2762397244 @default.
- W2974241014 cites W2768863537 @default.
- W2974241014 cites W2774314613 @default.
- W2974241014 cites W2782564735 @default.
- W2974241014 cites W2789369470 @default.
- W2974241014 cites W2796923525 @default.
- W2974241014 cites W2798054687 @default.
- W2974241014 cites W2957495611 @default.
- W2974241014 doi "https://doi.org/10.3390/ijms20194674" @default.
- W2974241014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6801397" @default.
- W2974241014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31547145" @default.
- W2974241014 hasPublicationYear "2019" @default.
- W2974241014 type Work @default.
- W2974241014 sameAs 2974241014 @default.
- W2974241014 citedByCount "23" @default.
- W2974241014 countsByYear W29742410142020 @default.
- W2974241014 countsByYear W29742410142021 @default.
- W2974241014 countsByYear W29742410142022 @default.
- W2974241014 countsByYear W29742410142023 @default.
- W2974241014 crossrefType "journal-article" @default.
- W2974241014 hasAuthorship W2974241014A5020310949 @default.
- W2974241014 hasAuthorship W2974241014A5031293890 @default.
- W2974241014 hasAuthorship W2974241014A5038926287 @default.
- W2974241014 hasAuthorship W2974241014A5042986203 @default.
- W2974241014 hasAuthorship W2974241014A5046728515 @default.
- W2974241014 hasAuthorship W2974241014A5050058929 @default.
- W2974241014 hasAuthorship W2974241014A5057441631 @default.
- W2974241014 hasAuthorship W2974241014A5062002935 @default.
- W2974241014 hasAuthorship W2974241014A5071308068 @default.
- W2974241014 hasAuthorship W2974241014A5075394738 @default.
- W2974241014 hasAuthorship W2974241014A5089506479 @default.
- W2974241014 hasBestOaLocation W29742410141 @default.
- W2974241014 hasConcept C126322002 @default.
- W2974241014 hasConcept C142724271 @default.
- W2974241014 hasConcept C2778548049 @default.
- W2974241014 hasConcept C2779134260 @default.
- W2974241014 hasConcept C2779483572 @default.
- W2974241014 hasConcept C2779651940 @default.
- W2974241014 hasConcept C2781197716 @default.