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• W2974295593 abstract "Summary Ustilago maydis is a model organism to study biotrophic plant-pathogen interactions. Sexual and pathogenic development of the fungus are tightly connected since fusion of compatible haploid sporidia is prerequisite for infection of the host plant, maize ( Zea mays ). After plant penetration, the unfolded protein response (UPR) is activated and required for biotrophic growth. The UPR is continuously active throughout all stages of pathogenic development in planta . However, since development of UPR deletion mutants stops directly after plant penetration, the role of an active UPR at later stages of development has/could not be examined, yet. Here, we establish a gene expression system for U. maydis that uses endogenous, conditionally active promoters to either induce or repress expression of a gene of interest during different stages of plant infection. Integration of the expression constructs into the native genomic locus and removal of resistance cassettes were required to obtain a wild type-like expression pattern. This indicates that genomic localization and chromatin structure are important for correct promoter activity and gene expression. By conditional expression of the central UPR regulator, Cib1, in U. maydis , we show that a functional UPR is required for continuous plant defense suppression after host infection and that U. maydis relies on a robust control system to prevent deleterious UPR hyperactivation." @default.
• W2974295593 created "2019-09-26" @default.
• W2974295593 creator A5013054814 @default.
• W2974295593 creator A5029665185 @default.
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• W2974295593 date "2019-09-19" @default.
• W2974295593 modified "2023-09-25" @default.
• W2974295593 title "Conditional gene expression reveals stage-specific functions of the unfolded protein response in the Ustilago maydis/maize pathosystem" @default.
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• W2974295593 doi "https://doi.org/10.1101/775692" @default.
• W2974295593 hasPublicationYear "2019" @default.
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