Matches in SemOpenAlex for { <https://semopenalex.org/work/W2974305135> ?p ?o ?g. }
- W2974305135 endingPage "1378" @default.
- W2974305135 startingPage "1378" @default.
- W2974305135 abstract "Cytochrome P450 (CYP) 17A1 is an important steroidogenic enzyme harboring 17α-hydroxylase and performing 17,20 lyase activities in multiple steps of steroid hormone synthesis, including dehydroepiandrosterone (DHEA) biosynthesis. Previously, we showed that CYP17A1-mediated DHEA production clearly protects glioblastomas from temozolomide-induced apoptosis, leading to drug resistance. Herein, we attempt to clarify whether the inhibition of CYP17A1 has a tumor-suppressive effect, and to determine the steroidogenesis-independent functions of CYP17A1 in glioblastomas. Abiraterone, an inhibitor of CYP17A1, significantly inhibits the proliferation of A172, T98G, and PT#3 (the primary glioblastoma cells) by inducing apoptosis. In parallel, abiraterone potently suppresses tumor growth in mouse models through transplantation of PT#3 cells to the back or to the brain. Based on evidence that abiraterone induces endoplasmic reticulum (ER) stress, followed by the accumulation of reactive oxygen species (ROS), CYP17A1 is important for ER health and redox homeostasis. To confirm our hypothesis, we showed that CYP17A1 overexpression prevents the initiation of ER stress and attenuates ROS production by regulating SAR1a/b expression. Abiraterone dissociates SAR1a/b from ER-localized CYP17A1, and induces SAR1a/b ubiquitination, leading to degradation. Furthermore, SAR1 overexpression rescues abiraterone-induced apoptosis and impairs redox homeostasis. In addition to steroid hormone synthesis, CYP17A1 associates with SAR1a/b to regulate protein processing and maintain ER health in glioblastomas." @default.
- W2974305135 created "2019-09-26" @default.
- W2974305135 creator A5004952365 @default.
- W2974305135 creator A5006066765 @default.
- W2974305135 creator A5011031545 @default.
- W2974305135 creator A5013291565 @default.
- W2974305135 creator A5021734865 @default.
- W2974305135 creator A5034407820 @default.
- W2974305135 creator A5057302814 @default.
- W2974305135 creator A5065378465 @default.
- W2974305135 creator A5080387374 @default.
- W2974305135 creator A5087776229 @default.
- W2974305135 date "2019-09-16" @default.
- W2974305135 modified "2023-10-18" @default.
- W2974305135 title "CYP17A1 Maintains the Survival of Glioblastomas by Regulating SAR1-Mediated Endoplasmic Reticulum Health and Redox Homeostasis" @default.
- W2974305135 cites W1946268637 @default.
- W2974305135 cites W1989552101 @default.
- W2974305135 cites W2026714211 @default.
- W2974305135 cites W2038597322 @default.
- W2974305135 cites W2039584947 @default.
- W2974305135 cites W2048865153 @default.
- W2974305135 cites W2055973066 @default.
- W2974305135 cites W2060382404 @default.
- W2974305135 cites W2068100113 @default.
- W2974305135 cites W2074200918 @default.
- W2974305135 cites W2092179351 @default.
- W2974305135 cites W2139086060 @default.
- W2974305135 cites W2140300092 @default.
- W2974305135 cites W2143510811 @default.
- W2974305135 cites W2155322709 @default.
- W2974305135 cites W2159268490 @default.
- W2974305135 cites W2166396390 @default.
- W2974305135 cites W2265514567 @default.
- W2974305135 cites W2347046562 @default.
- W2974305135 cites W2399237148 @default.
- W2974305135 cites W2462797823 @default.
- W2974305135 cites W2521224740 @default.
- W2974305135 cites W2521911213 @default.
- W2974305135 cites W2618579614 @default.
- W2974305135 cites W2722558008 @default.
- W2974305135 cites W2744265558 @default.
- W2974305135 cites W2750662929 @default.
- W2974305135 cites W2793234310 @default.
- W2974305135 cites W2793236705 @default.
- W2974305135 cites W2884888259 @default.
- W2974305135 cites W2898590915 @default.
- W2974305135 cites W2906752223 @default.
- W2974305135 doi "https://doi.org/10.3390/cancers11091378" @default.
- W2974305135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6770831" @default.
- W2974305135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31527549" @default.
- W2974305135 hasPublicationYear "2019" @default.
- W2974305135 type Work @default.
- W2974305135 sameAs 2974305135 @default.
- W2974305135 citedByCount "21" @default.
- W2974305135 countsByYear W29743051352019 @default.
- W2974305135 countsByYear W29743051352020 @default.
- W2974305135 countsByYear W29743051352021 @default.
- W2974305135 countsByYear W29743051352022 @default.
- W2974305135 countsByYear W29743051352023 @default.
- W2974305135 crossrefType "journal-article" @default.
- W2974305135 hasAuthorship W2974305135A5004952365 @default.
- W2974305135 hasAuthorship W2974305135A5006066765 @default.
- W2974305135 hasAuthorship W2974305135A5011031545 @default.
- W2974305135 hasAuthorship W2974305135A5013291565 @default.
- W2974305135 hasAuthorship W2974305135A5021734865 @default.
- W2974305135 hasAuthorship W2974305135A5034407820 @default.
- W2974305135 hasAuthorship W2974305135A5057302814 @default.
- W2974305135 hasAuthorship W2974305135A5065378465 @default.
- W2974305135 hasAuthorship W2974305135A5080387374 @default.
- W2974305135 hasAuthorship W2974305135A5087776229 @default.
- W2974305135 hasBestOaLocation W29743051351 @default.
- W2974305135 hasConcept C134018914 @default.
- W2974305135 hasConcept C139447449 @default.
- W2974305135 hasConcept C142716871 @default.
- W2974305135 hasConcept C158617107 @default.
- W2974305135 hasConcept C181199279 @default.
- W2974305135 hasConcept C185592680 @default.
- W2974305135 hasConcept C190283241 @default.
- W2974305135 hasConcept C502942594 @default.
- W2974305135 hasConcept C55493867 @default.
- W2974305135 hasConcept C86803240 @default.
- W2974305135 hasConcept C95444343 @default.
- W2974305135 hasConceptScore W2974305135C134018914 @default.
- W2974305135 hasConceptScore W2974305135C139447449 @default.
- W2974305135 hasConceptScore W2974305135C142716871 @default.
- W2974305135 hasConceptScore W2974305135C158617107 @default.
- W2974305135 hasConceptScore W2974305135C181199279 @default.
- W2974305135 hasConceptScore W2974305135C185592680 @default.
- W2974305135 hasConceptScore W2974305135C190283241 @default.
- W2974305135 hasConceptScore W2974305135C502942594 @default.
- W2974305135 hasConceptScore W2974305135C55493867 @default.
- W2974305135 hasConceptScore W2974305135C86803240 @default.
- W2974305135 hasConceptScore W2974305135C95444343 @default.
- W2974305135 hasFunder F4320322795 @default.
- W2974305135 hasIssue "9" @default.
- W2974305135 hasLocation W29743051351 @default.
- W2974305135 hasLocation W29743051352 @default.
- W2974305135 hasLocation W29743051353 @default.