Matches in SemOpenAlex for { <https://semopenalex.org/work/W2974328106> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2974328106 endingPage "137" @default.
- W2974328106 startingPage "129" @default.
- W2974328106 abstract "Uveal melanoma (UM) is the most common intraocular tumour in adults. Currently there are different tests available to determine the risk of UM for metastasis, among which include BRCA1-associated protein-1 (BAP1) immunohistochemistry (IHC) and gene expression profiling (GEP). BAP1 is a deubiquitylating enzyme (DUB) that has tumour suppressor activity, the loss of which therefore is associated with higher risk for tumour growth and metastasis.To compare and correlate the prognostic significance of BAP1-IHC staining patterns and GEP in the prediction of UM's risk for metastasis.This is a retrospective chart review with prospective follow-up of patients with primary UM who underwent enucleation from the year 2008 to 2018. Clinical history, histopathologic findings, GEP classification, BAP1-IHC of the formalin-fixed paraffin-embedded tissues, and follow-up data for metastasis were collected and statistically analysed.A total of 30 enucleated eyes with UM were included in the study. All class 1a tumours had high nuclear BAP1 expression and all class 2 had low nuclear BAP1 expression. Fifty percent of the class 1b tumours had low nuclear BAP1 expression. Among the tumours with low nuclear BAP1 expression, 68% developed metastasis, while 9% developed metastasis among high nuclear expression. Fifty-five percent developed metastasis in tumours with high cytoplasmic expression and 42% for low cytoplasmic expression. Predictive values for metastasis (positive predictive value, negative predictive value) are as follows: (1) nuclear BAP1-IHC (68%, 91%), (2) cytoplasmic BAP1-IHC (55%, 58%), and (3) GEP (73%, 80%). Nuclear BAP1-IHC and GEP had the same accuracy rate of 77% and cytoplasmic BAP1-IHC had an accuracy of 57%.Low nuclear BAP1-IHC strongly correlates with GEP class 2 and was equally accurate in the prediction of metastasis." @default.
- W2974328106 created "2019-09-26" @default.
- W2974328106 creator A5020390056 @default.
- W2974328106 creator A5054360365 @default.
- W2974328106 creator A5056669160 @default.
- W2974328106 creator A5057277785 @default.
- W2974328106 date "2019-09-19" @default.
- W2974328106 modified "2023-10-17" @default.
- W2974328106 title "BAP1 Immunoreactivity Correlates with Gene Expression Class in Uveal Melanoma" @default.
- W2974328106 cites W135866504 @default.
- W2974328106 cites W1973904343 @default.
- W2974328106 cites W1974951000 @default.
- W2974328106 cites W1990403579 @default.
- W2974328106 cites W2033722975 @default.
- W2974328106 cites W2049866899 @default.
- W2974328106 cites W2055835855 @default.
- W2974328106 cites W2057802075 @default.
- W2974328106 cites W2067354849 @default.
- W2974328106 cites W2072355125 @default.
- W2974328106 cites W2077457197 @default.
- W2974328106 cites W2099293633 @default.
- W2974328106 cites W2136802909 @default.
- W2974328106 cites W2158929973 @default.
- W2974328106 cites W2159446177 @default.
- W2974328106 cites W2169503644 @default.
- W2974328106 cites W2173082167 @default.
- W2974328106 cites W2311959388 @default.
- W2974328106 cites W2326993272 @default.
- W2974328106 cites W2343512379 @default.
- W2974328106 cites W2743542866 @default.
- W2974328106 cites W2746164323 @default.
- W2974328106 cites W2762938139 @default.
- W2974328106 cites W2790551104 @default.
- W2974328106 cites W2800131220 @default.
- W2974328106 doi "https://doi.org/10.1159/000502550" @default.
- W2974328106 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7109388" @default.
- W2974328106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32258021" @default.
- W2974328106 hasPublicationYear "2019" @default.
- W2974328106 type Work @default.
- W2974328106 sameAs 2974328106 @default.
- W2974328106 citedByCount "20" @default.
- W2974328106 countsByYear W29743281062019 @default.
- W2974328106 countsByYear W29743281062021 @default.
- W2974328106 countsByYear W29743281062022 @default.
- W2974328106 countsByYear W29743281062023 @default.
- W2974328106 crossrefType "journal-article" @default.
- W2974328106 hasAuthorship W2974328106A5020390056 @default.
- W2974328106 hasAuthorship W2974328106A5054360365 @default.
- W2974328106 hasAuthorship W2974328106A5056669160 @default.
- W2974328106 hasAuthorship W2974328106A5057277785 @default.
- W2974328106 hasBestOaLocation W29743281061 @default.
- W2974328106 hasConcept C121608353 @default.
- W2974328106 hasConcept C126322002 @default.
- W2974328106 hasConcept C141071460 @default.
- W2974328106 hasConcept C142724271 @default.
- W2974328106 hasConcept C143998085 @default.
- W2974328106 hasConcept C188261085 @default.
- W2974328106 hasConcept C204232928 @default.
- W2974328106 hasConcept C2777658100 @default.
- W2974328106 hasConcept C2779013556 @default.
- W2974328106 hasConcept C37846818 @default.
- W2974328106 hasConcept C502942594 @default.
- W2974328106 hasConcept C71924100 @default.
- W2974328106 hasConceptScore W2974328106C121608353 @default.
- W2974328106 hasConceptScore W2974328106C126322002 @default.
- W2974328106 hasConceptScore W2974328106C141071460 @default.
- W2974328106 hasConceptScore W2974328106C142724271 @default.
- W2974328106 hasConceptScore W2974328106C143998085 @default.
- W2974328106 hasConceptScore W2974328106C188261085 @default.
- W2974328106 hasConceptScore W2974328106C204232928 @default.
- W2974328106 hasConceptScore W2974328106C2777658100 @default.
- W2974328106 hasConceptScore W2974328106C2779013556 @default.
- W2974328106 hasConceptScore W2974328106C37846818 @default.
- W2974328106 hasConceptScore W2974328106C502942594 @default.
- W2974328106 hasConceptScore W2974328106C71924100 @default.
- W2974328106 hasIssue "2" @default.
- W2974328106 hasLocation W29743281061 @default.
- W2974328106 hasLocation W29743281062 @default.
- W2974328106 hasLocation W29743281063 @default.
- W2974328106 hasOpenAccess W2974328106 @default.
- W2974328106 hasPrimaryLocation W29743281061 @default.
- W2974328106 hasRelatedWork W2022389141 @default.
- W2974328106 hasRelatedWork W2032940085 @default.
- W2974328106 hasRelatedWork W2159897971 @default.
- W2974328106 hasRelatedWork W2378664397 @default.
- W2974328106 hasRelatedWork W2381544267 @default.
- W2974328106 hasRelatedWork W2772590242 @default.
- W2974328106 hasRelatedWork W2777626578 @default.
- W2974328106 hasRelatedWork W2964433561 @default.
- W2974328106 hasRelatedWork W3028163481 @default.
- W2974328106 hasRelatedWork W3045875506 @default.
- W2974328106 hasVolume "6" @default.
- W2974328106 isParatext "false" @default.
- W2974328106 isRetracted "false" @default.
- W2974328106 magId "2974328106" @default.
- W2974328106 workType "article" @default.