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- W2974328145 abstract "Suppressor of Hairless [Su(H)], the transcription factor at the end of the Notch pathway in Drosophila, utilizes the Hairless protein to recruit two co-repressors, Groucho (Gro) and C-terminal Binding Protein (CtBP), indirectly. Hairless is present only in the Pancrustacea, raising the question of how Su(H) in other protostomes gains repressive function. We show that Su(H) from a wide array of arthropods, molluscs, and annelids includes motifs that directly bind Gro and CtBP; thus, direct co-repressor recruitment is ancestral in the protostomes. How did Hairless come to replace this ancestral paradigm? Our discovery of a protein (S-CAP) in Myriapods and Chelicerates that contains a motif similar to the Su(H)-binding domain in Hairless has revealed a likely evolutionary connection between Hairless and Metastasis-associated (MTA) protein, a component of the NuRD complex. Sequence comparison and widely conserved microsynteny suggest that S-CAP and Hairless arose from a tandem duplication of an ancestral MTA gene." @default.
- W2974328145 created "2019-09-26" @default.
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- W2974328145 date "2019-09-23" @default.
- W2974328145 modified "2023-10-08" @default.
- W2974328145 title "Evolutionary emergence of Hairless as a novel component of the Notch signaling pathway" @default.
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- W2974328145 doi "https://doi.org/10.7554/elife.48115" @default.
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- W2974328145 hasPublicationYear "2019" @default.
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