FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2974334772> ?p ?o ?g. }

• W2974334772 abstract "ABSTRACT The CYD-TDV vaccine was recently developed to combat dengue, a mosquito-borne viral disease that afflicts millions of people each year throughout the tropical and subtropical world. Its rollout has been complicated by recent findings that vaccinees with no prior exposure to dengue virus (DENV) experience an elevated risk of severe disease in response to their first DENV infection subsequent to vaccination. As a result of these findings, guidelines for use of CYD-TDV now require serological screening prior to vaccination to establish that an individual does not fall into this high-risk category. These complications mean that the public health impact of CYD-TDV vaccination is expected to be higher in areas with higher transmission. One important practical difficulty with tailoring vaccination policy to local transmission contexts is that DENV transmission is spatially heterogeneous, even at the scale of neighborhoods or blocks within a city. This raises the question of whether models based on data that average over spatial heterogeneity in transmission could fail to capture important aspects of CYD-TDV impact in spatially heterogeneous populations. We explored this question with a deterministic model of DENV transmission and CYD-TDV vaccination in a population comprised of two communities with differing transmission intensities. Compared to the full model, a version of the model based on the average of the two communities failed to capture benefits of targeting the intervention to the high-transmission community, which resulted in greater impact in both communities than we observed under even coverage. In addition, the model based on the average of the two communities substantially overestimated impact among vaccinated individuals in the low-transmission community. In the event that the specificity of serological screening is not high, this result suggests that models that ignore spatial heterogeneity could overlook the potential for harm to this segment of the population." @default.
• W2974334772 created "2019-09-26" @default.
• W2974334772 creator A5002153541 @default.
• W2974334772 creator A5050011389 @default.
• W2974334772 date "2019-09-16" @default.
• W2974334772 modified "2023-10-10" @default.
• W2974334772 title "Hidden heterogeneity and its influence on dengue vaccination impact" @default.
• W2974334772 cites W1846320330 @default.
• W2974334772 cites W1991241508 @default.
• W2974334772 cites W2004106419 @default.
• W2974334772 cites W2028387003 @default.
• W2974334772 cites W2064738366 @default.
• W2974334772 cites W2074065103 @default.
• W2974334772 cites W2075445009 @default.
• W2974334772 cites W2105874738 @default.
• W2974334772 cites W2111032242 @default.
• W2974334772 cites W2111358957 @default.
• W2974334772 cites W2112700637 @default.
• W2974334772 cites W2147797256 @default.
• W2974334772 cites W2158335699 @default.
• W2974334772 cites W2161093157 @default.
• W2974334772 cites W2162301084 @default.
• W2974334772 cites W2189694299 @default.
• W2974334772 cites W2262727519 @default.
• W2974334772 cites W2305558436 @default.
• W2974334772 cites W2310092046 @default.
• W2974334772 cites W2407506781 @default.
• W2974334772 cites W2408265715 @default.
• W2974334772 cites W2467534132 @default.
• W2974334772 cites W2485442366 @default.
• W2974334772 cites W2510055542 @default.
• W2974334772 cites W2511118048 @default.
• W2974334772 cites W2520556610 @default.
• W2974334772 cites W2559305335 @default.
• W2974334772 cites W2580689161 @default.
• W2974334772 cites W2593596007 @default.
• W2974334772 cites W2765619750 @default.
• W2974334772 cites W2774571722 @default.
• W2974334772 cites W2793228617 @default.
• W2974334772 cites W2793899222 @default.
• W2974334772 cites W2803273577 @default.
• W2974334772 cites W2807907731 @default.
• W2974334772 cites W2807989886 @default.
• W2974334772 cites W2808583541 @default.
• W2974334772 cites W2892299706 @default.
• W2974334772 cites W2912350319 @default.
• W2974334772 cites W2920135474 @default.
• W2974334772 cites W2925267709 @default.
• W2974334772 cites W2940111722 @default.
• W2974334772 cites W2942326501 @default.
• W2974334772 cites W2945975544 @default.
• W2974334772 cites W2952094509 @default.
• W2974334772 cites W2953405752 @default.
• W2974334772 cites W2965279952 @default.
• W2974334772 cites W4211135732 @default.
• W2974334772 cites W989848165 @default.
• W2974334772 doi "https://doi.org/10.1101/19006783" @default.
• W2974334772 hasPublicationYear "2019" @default.
• W2974334772 type Work @default.
• W2974334772 sameAs 2974334772 @default.
• W2974334772 citedByCount "0" @default.
• W2974334772 crossrefType "posted-content" @default.
• W2974334772 hasAuthorship W2974334772A5002153541 @default.
• W2974334772 hasAuthorship W2974334772A5050011389 @default.
• W2974334772 hasBestOaLocation W29743347721 @default.
• W2974334772 hasConcept C118552586 @default.
• W2974334772 hasConcept C144024400 @default.
• W2974334772 hasConcept C149923435 @default.
• W2974334772 hasConcept C203014093 @default.
• W2974334772 hasConcept C205649164 @default.
• W2974334772 hasConcept C22070199 @default.
• W2974334772 hasConcept C2779308166 @default.
• W2974334772 hasConcept C2779635636 @default.
• W2974334772 hasConcept C2780665704 @default.
• W2974334772 hasConcept C2908647359 @default.
• W2974334772 hasConcept C41008148 @default.
• W2974334772 hasConcept C533803919 @default.
• W2974334772 hasConcept C71924100 @default.
• W2974334772 hasConcept C761482 @default.
• W2974334772 hasConcept C76155785 @default.
• W2974334772 hasConcept C99454951 @default.
• W2974334772 hasConceptScore W2974334772C118552586 @default.
• W2974334772 hasConceptScore W2974334772C144024400 @default.
• W2974334772 hasConceptScore W2974334772C149923435 @default.
• W2974334772 hasConceptScore W2974334772C203014093 @default.
• W2974334772 hasConceptScore W2974334772C205649164 @default.
• W2974334772 hasConceptScore W2974334772C22070199 @default.
• W2974334772 hasConceptScore W2974334772C2779308166 @default.
• W2974334772 hasConceptScore W2974334772C2779635636 @default.
• W2974334772 hasConceptScore W2974334772C2780665704 @default.
• W2974334772 hasConceptScore W2974334772C2908647359 @default.
• W2974334772 hasConceptScore W2974334772C41008148 @default.
• W2974334772 hasConceptScore W2974334772C533803919 @default.
• W2974334772 hasConceptScore W2974334772C71924100 @default.
• W2974334772 hasConceptScore W2974334772C761482 @default.
• W2974334772 hasConceptScore W2974334772C76155785 @default.
• W2974334772 hasConceptScore W2974334772C99454951 @default.
• W2974334772 hasLocation W29743347721 @default.
• W2974334772 hasLocation W29743347722 @default.
• W2974334772 hasOpenAccess W2974334772 @default.

• next