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- W2974372755 endingPage "2062" @default.
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- W2974372755 abstract "Aim: The current limitations of antiplatelet therapy promote the search for new antithrombotic agents. Here we describe novel platelet aggregation inhibitors that combine pyridazinone and coumarin scaffolds in their structure. Results: The target compounds were synthesized in good yield from maleic anhydride, following a multistep strategy. The in vitro studies demonstrated significant antiplatelet activity in many of these compounds, with IC 50 values in the low micromolar range, revealing that the activity was affected by the substitution pattern of the two selected cores. Additional studies point out their effect as inhibitors of glycoprotein (Gp) IIb/IIIa activation. Conclusion: This novel hybrid structure can be considered a good prototype for the development of potent platelet aggregation inhibitors." @default.
- W2974372755 created "2019-09-26" @default.
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- W2974372755 date "2019-08-01" @default.
- W2974372755 modified "2023-10-16" @default.
- W2974372755 title "Novel compounds of hybrid structure pyridazinone–coumarin as potent inhibitors of platelet aggregation" @default.
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- W2974372755 doi "https://doi.org/10.4155/fmc-2018-0373" @default.
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