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• W2974397777 abstract "Rationale: Obesity leads to resistant hypertension and mechanisms are poorly understood, but high plasma levels of leptin have been implicated. Leptin increases blood pressure acting both centrally in the dorsomedial hypothalamus and peripherally. Sites of the peripheral hypertensive effect of leptin have not been identified. We previously reported that leptin enhanced activity of the carotid sinus nerve, which transmits chemosensory input from the carotid bodies (CBs) to the medullary centers, and this effect was abolished by nonselective blockers of Trp (transient receptor potential) channels. We searched our mouse CB transcriptome database and found that the Trpm7 (transient receptor potential melastatin 7) channel was the most abundant Trp channel. Objective: To examine if leptin induces hypertension acting on the CB Trpm7. Methods and Results: C57BL/6J (n=79), leptin receptor ( LepR b ) deficient db/db mice (n=22), and LepRb-EGFP (n=4) mice were used. CB Trpm7 and LepR b gene expression was determined and immunohistochemistry was performed; CB glomus cells were isolated and Trpm7-like current was recorded. Blood pressure was recorded continuously in (1) leptin-treated C57BL/6J mice with intact and denervated CB; (2) leptin-treated C57BL/6J mice, which also received a nonselective Trpm7 blocker FTY720 administered systemically or topically to the CB area; (3) leptin-treated C57BL/6J mice transfected with Trpm7 small hairpin RNA to the CB, and (4) Lepr b deficient obese db/db mice before and after Lepr b expression in CB. Leptin receptor and Trpm7 colocalized in the CB glomus cells. Leptin induced a nonselective cation current in these cells, which was inhibited by Trpm7 blockers. Leptin induced hypertension in C57BL/6J mice, which was abolished by CB denervation, Trpm 7 blockers, and Trpm7 small hairpin RNA applied to CBs. Lepr b overexpression in CB of Lepr b -deficient db/db mice demethylated the Trpm7 promoter, increased Trpm7 gene expression, and induced hypertension. Conclusions: We conclude that leptin induces hypertension acting on Trmp7 in CB, which opens horizons for new therapy." @default.
• W2974397777 created "2019-09-26" @default.
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• W2974397777 date "2019-11-08" @default.
• W2974397777 modified "2023-10-10" @default.
• W2974397777 title "Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body" @default.
• W2974397777 cites W1512074319 @default.
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• W2974397777 cites W1971216836 @default.
• W2974397777 cites W1973026818 @default.
• W2974397777 cites W1991386587 @default.
• W2974397777 cites W1992857656 @default.
• W2974397777 cites W1999340472 @default.
• W2974397777 cites W2002736272 @default.
• W2974397777 cites W2007586531 @default.
• W2974397777 cites W2011084159 @default.
• W2974397777 cites W2011168498 @default.
• W2974397777 cites W2012416246 @default.
• W2974397777 cites W2014093920 @default.
• W2974397777 cites W2015207227 @default.
• W2974397777 cites W2020172718 @default.
• W2974397777 cites W2022121838 @default.
• W2974397777 cites W2027427622 @default.
• W2974397777 cites W2046723830 @default.
• W2974397777 cites W2047923125 @default.
• W2974397777 cites W2051192888 @default.
• W2974397777 cites W2064365050 @default.
• W2974397777 cites W2066295481 @default.
• W2974397777 cites W2066581734 @default.
• W2974397777 cites W2070013078 @default.
• W2974397777 cites W2070651032 @default.
• W2974397777 cites W2072206476 @default.
• W2974397777 cites W2072799789 @default.
• W2974397777 cites W2075230686 @default.
• W2974397777 cites W2091512107 @default.
• W2974397777 cites W2102025441 @default.
• W2974397777 cites W2104948944 @default.
• W2974397777 cites W2110690965 @default.
• W2974397777 cites W2117834225 @default.
• W2974397777 cites W2125510262 @default.
• W2974397777 cites W2125893767 @default.
• W2974397777 cites W2144375073 @default.
• W2974397777 cites W2144562937 @default.
• W2974397777 cites W2147984307 @default.
• W2974397777 cites W2150966205 @default.
• W2974397777 cites W2152628928 @default.
• W2974397777 cites W2153376781 @default.
• W2974397777 cites W2156783552 @default.
• W2974397777 cites W2160581545 @default.
• W2974397777 cites W2164173823 @default.
• W2974397777 cites W2164180841 @default.
• W2974397777 cites W2181569425 @default.
• W2974397777 cites W2189916494 @default.
• W2974397777 cites W2267348707 @default.
• W2974397777 cites W2326795588 @default.
• W2974397777 cites W2333904745 @default.
• W2974397777 cites W2334337188 @default.
• W2974397777 cites W2383859278 @default.
• W2974397777 cites W2463358284 @default.
• W2974397777 cites W2508492660 @default.
• W2974397777 cites W2516502922 @default.
• W2974397777 cites W2777047268 @default.
• W2974397777 cites W2794493124 @default.
• W2974397777 cites W2804520402 @default.
• W2974397777 cites W2885409766 @default.
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• W2974397777 doi "https://doi.org/10.1161/circresaha.119.315338" @default.
• W2974397777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6842127" @default.
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• W2974397777 hasPublicationYear "2019" @default.
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