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- W2974471972 abstract "Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose), an ellagitannin, is one of the major bioactive compounds present in various plants. Ellagitannins belong to the hydrolyzable tannins, a group of polyphenols. Corilagin shows broad-spectrum biological, and therapeutic activities, such as antioxidant, anti-inflammatory, hepatoprotective, and antitumor actions. Natural compounds possessing antitumor activities have attracted significant attention for treatment of cancer. Corilagin has shown inhibitory activity against the growth of numerous cancer cells by prompting cell cycle arrest at the G2/M phase and augmented apoptosis. Corilagin-induced apoptosis and autophagic cell death depends on production of intracellular reactive oxygen species in breast cancer cell line. It blocks the activation of both the canonical Smad and non-canonical extracellular-signal-regulated kinase/Akt (protein kinase B) pathways. The potential apoptotic action of corilagin is mediated by altered expression of procaspase-3, procaspase-8, procaspase-9, poly (ADP ribose) polymerase, and Bcl-2 Bax. In nude mice, corilagin suppressed cholangiocarcinoma growth and downregulated the expression of Notch1 and mammalian target of rapamycin. The aim of this review is to summarize the anticancer efficacy of corilagin with an emphasis on the molecular mechanisms involving various signaling pathways in tumor cells." @default.
- W2974471972 created "2019-09-26" @default.
- W2974471972 creator A5002194763 @default.
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- W2974471972 date "2019-09-19" @default.
- W2974471972 modified "2023-10-17" @default.
- W2974471972 title "Corilagin in Cancer: A Critical Evaluation of Anticancer Activities and Molecular Mechanisms" @default.
- W2974471972 cites W1512707729 @default.
- W2974471972 cites W1549679997 @default.
- W2974471972 cites W1600828823 @default.
- W2974471972 cites W1675385852 @default.
- W2974471972 cites W1751749102 @default.
- W2974471972 cites W1757407923 @default.
- W2974471972 cites W1863901809 @default.
- W2974471972 cites W1966739930 @default.
- W2974471972 cites W1967296007 @default.
- W2974471972 cites W1970398458 @default.
- W2974471972 cites W1972345203 @default.
- W2974471972 cites W1973667353 @default.
- W2974471972 cites W1973932577 @default.
- W2974471972 cites W1978009910 @default.
- W2974471972 cites W1978045533 @default.
- W2974471972 cites W1978146894 @default.
- W2974471972 cites W1979032223 @default.
- W2974471972 cites W1984716159 @default.
- W2974471972 cites W1985425629 @default.
- W2974471972 cites W1987383598 @default.
- W2974471972 cites W1989509230 @default.
- W2974471972 cites W1990098574 @default.
- W2974471972 cites W1990362555 @default.
- W2974471972 cites W1993384358 @default.
- W2974471972 cites W1993956391 @default.
- W2974471972 cites W1994267601 @default.
- W2974471972 cites W1997801717 @default.
- W2974471972 cites W1998249167 @default.
- W2974471972 cites W1999141617 @default.
- W2974471972 cites W1999381112 @default.
- W2974471972 cites W1999581210 @default.
- W2974471972 cites W2006095859 @default.
- W2974471972 cites W2011996984 @default.
- W2974471972 cites W2012749338 @default.
- W2974471972 cites W2013190055 @default.
- W2974471972 cites W2014624232 @default.
- W2974471972 cites W2014964773 @default.
- W2974471972 cites W2015407907 @default.
- W2974471972 cites W2019154144 @default.
- W2974471972 cites W2020830322 @default.
- W2974471972 cites W2021700011 @default.
- W2974471972 cites W2023168867 @default.
- W2974471972 cites W2028535996 @default.
- W2974471972 cites W2028848055 @default.
- W2974471972 cites W2028956857 @default.
- W2974471972 cites W2033143975 @default.
- W2974471972 cites W2034676357 @default.
- W2974471972 cites W2037038224 @default.
- W2974471972 cites W2040143484 @default.
- W2974471972 cites W2044977925 @default.
- W2974471972 cites W2045986779 @default.
- W2974471972 cites W2046977695 @default.
- W2974471972 cites W2047463940 @default.
- W2974471972 cites W2050276816 @default.
- W2974471972 cites W2050859935 @default.
- W2974471972 cites W2052605153 @default.
- W2974471972 cites W2054240199 @default.
- W2974471972 cites W2056779336 @default.
- W2974471972 cites W2057666608 @default.
- W2974471972 cites W2058297837 @default.
- W2974471972 cites W2059649655 @default.
- W2974471972 cites W2060204808 @default.
- W2974471972 cites W2060922482 @default.
- W2974471972 cites W2066300715 @default.
- W2974471972 cites W2066560125 @default.
- W2974471972 cites W2066748962 @default.
- W2974471972 cites W2067501010 @default.
- W2974471972 cites W2067670322 @default.
- W2974471972 cites W2071753454 @default.
- W2974471972 cites W2071966184 @default.
- W2974471972 cites W2074688366 @default.
- W2974471972 cites W2075238843 @default.
- W2974471972 cites W2076156155 @default.
- W2974471972 cites W2078411029 @default.
- W2974471972 cites W2081731746 @default.
- W2974471972 cites W2082453683 @default.
- W2974471972 cites W2083249555 @default.
- W2974471972 cites W2084803188 @default.
- W2974471972 cites W2086580254 @default.
- W2974471972 cites W2087028843 @default.
- W2974471972 cites W2088473501 @default.
- W2974471972 cites W20888715 @default.
- W2974471972 cites W2089430837 @default.
- W2974471972 cites W2092276732 @default.