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• W2974506773 abstract "High-risk resectable melanoma poses therapeutic challenges as this subgroup remains most vulnerable for disease recurrence. Immunotherapy has established its efficacy in cases of advanced melanoma, and now is actively being investigated in the multimodal management of resectable disease. Daromun, an intralesional immunocytokine, has emerged as a unique immunotherapy in its ability to preferentially target tumor cells, resulting in direct destruction, while generating a bystander effect that leads to a distant treatment effect. On the basis of its mechanism of action, there is growing interest in delivering immune-based therapies in a neoadjuvant setting. In this review, the neo-DREAM study, a Phase III trial comparing the safety and efficacy of neoadjuvant Daromun for resectable stage IIIB/C melanoma will be described. Clinical Trial Registration Number: NCT03567889" @default.
• W2974506773 created "2019-09-26" @default.
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• W2974506773 date "2019-11-01" @default.
• W2974506773 modified "2023-10-13" @default.
• W2974506773 title "Neo-DREAM study investigating Daromun for the treatment of clinical stage IIIB/C melanoma" @default.
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• W2974506773 doi "https://doi.org/10.2217/fon-2019-0433" @default.
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