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- W2974513151 abstract "Thioredoxin-interacting protein (TXNIP) is a multifunctional protein that regulates glucose metabolism and cellular redox state, the latter by binding and inhibiting the endogenous antioxidant thioredoxin. TXNIP is markedly upregulated by high glucose (HG) and we previously showed that STZ-induced diabetic TXNIP-/- mice are protected from developing features of diabetic nephropathy (DN). The pathogenesis of diabetes complications involves the oxidative inhibition of the glycolytic enzyme GAPDH, resulting in aberrant glucose metabolism." @default.
- W2974513151 created "2019-09-26" @default.
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- W2974513151 date "2019-10-01" @default.
- W2974513151 modified "2023-09-25" @default.
- W2974513151 title "7 - TXNIP Promotes GAPDH Nuclear Translocation by High Glucose" @default.
- W2974513151 doi "https://doi.org/10.1016/j.jcjd.2019.07.014" @default.
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