Matches in SemOpenAlex for { <https://semopenalex.org/work/W2974553306> ?p ?o ?g. }
- W2974553306 abstract "Abstract ST8 alpha- N -acetyl-neuraminide alpha-2,8-sialyltransferase 2 (ST8SIA2) synthesizes polysialic acid (PSA), which is essential for brain development. Although previous studies reported that St8sia2 -deficient mice that have a mixed 129 and C57BL/6 (B6) genetic background showed mild and variable phenotypes, the reasons for this remain unknown. We hypothesized that this phenotypic difference is caused by diversity in the expression or function of flanking genes of St8sia2 . A genomic polymorphism and gene expression analysis in the flanking region revealed reduced expression of insulin-like growth factor 1 receptor ( Igf1r ) on the B6 background than on that of the 129 strain. This observation, along with the finding that administration of an IGF1R agonist during pregnancy increased litter size, suggests that the decreased expression of Igf1r associated with ST8SIA2 deficiency caused lethality. This study demonstrates the importance of gene expression level in the flanking regions of a targeted null allele having an effect on phenotype." @default.
- W2974553306 created "2019-09-26" @default.
- W2974553306 creator A5005034149 @default.
- W2974553306 creator A5019310996 @default.
- W2974553306 creator A5035774490 @default.
- W2974553306 creator A5036040469 @default.
- W2974553306 creator A5036143680 @default.
- W2974553306 creator A5052647481 @default.
- W2974553306 creator A5053463839 @default.
- W2974553306 creator A5063296582 @default.
- W2974553306 creator A5081666335 @default.
- W2974553306 date "2019-09-20" @default.
- W2974553306 modified "2023-10-16" @default.
- W2974553306 title "Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice" @default.
- W2974553306 cites W1633996651 @default.
- W2974553306 cites W1963756597 @default.
- W2974553306 cites W1969157787 @default.
- W2974553306 cites W1969275043 @default.
- W2974553306 cites W1975317274 @default.
- W2974553306 cites W1977855433 @default.
- W2974553306 cites W1977966461 @default.
- W2974553306 cites W1979938245 @default.
- W2974553306 cites W1985425785 @default.
- W2974553306 cites W1991703748 @default.
- W2974553306 cites W2001145498 @default.
- W2974553306 cites W2004213733 @default.
- W2974553306 cites W2004444318 @default.
- W2974553306 cites W2005658352 @default.
- W2974553306 cites W2006535362 @default.
- W2974553306 cites W2011477466 @default.
- W2974553306 cites W2019986705 @default.
- W2974553306 cites W2022698715 @default.
- W2974553306 cites W2034703095 @default.
- W2974553306 cites W2047075413 @default.
- W2974553306 cites W2073636233 @default.
- W2974553306 cites W2078528462 @default.
- W2974553306 cites W2083563512 @default.
- W2974553306 cites W2085893147 @default.
- W2974553306 cites W2088970596 @default.
- W2974553306 cites W2093575688 @default.
- W2974553306 cites W2099000660 @default.
- W2974553306 cites W2099983388 @default.
- W2974553306 cites W2100343582 @default.
- W2974553306 cites W2109574989 @default.
- W2974553306 cites W2116053845 @default.
- W2974553306 cites W2120815676 @default.
- W2974553306 cites W2126414144 @default.
- W2974553306 cites W2127905906 @default.
- W2974553306 cites W2146856288 @default.
- W2974553306 cites W2148393306 @default.
- W2974553306 cites W2153491115 @default.
- W2974553306 cites W2155058041 @default.
- W2974553306 cites W2168230267 @default.
- W2974553306 cites W2169572161 @default.
- W2974553306 cites W2169935198 @default.
- W2974553306 cites W2322747038 @default.
- W2974553306 cites W2603211178 @default.
- W2974553306 doi "https://doi.org/10.1038/s41598-019-50006-5" @default.
- W2974553306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6754417" @default.
- W2974553306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31541165" @default.
- W2974553306 hasPublicationYear "2019" @default.
- W2974553306 type Work @default.
- W2974553306 sameAs 2974553306 @default.
- W2974553306 citedByCount "4" @default.
- W2974553306 countsByYear W29745533062021 @default.
- W2974553306 countsByYear W29745533062022 @default.
- W2974553306 countsByYear W29745533062023 @default.
- W2974553306 crossrefType "journal-article" @default.
- W2974553306 hasAuthorship W2974553306A5005034149 @default.
- W2974553306 hasAuthorship W2974553306A5019310996 @default.
- W2974553306 hasAuthorship W2974553306A5035774490 @default.
- W2974553306 hasAuthorship W2974553306A5036040469 @default.
- W2974553306 hasAuthorship W2974553306A5036143680 @default.
- W2974553306 hasAuthorship W2974553306A5052647481 @default.
- W2974553306 hasAuthorship W2974553306A5053463839 @default.
- W2974553306 hasAuthorship W2974553306A5063296582 @default.
- W2974553306 hasAuthorship W2974553306A5081666335 @default.
- W2974553306 hasBestOaLocation W29745533061 @default.
- W2974553306 hasConcept C104317684 @default.
- W2974553306 hasConcept C122871604 @default.
- W2974553306 hasConcept C127716648 @default.
- W2974553306 hasConcept C144174609 @default.
- W2974553306 hasConcept C1491633281 @default.
- W2974553306 hasConcept C150194340 @default.
- W2974553306 hasConcept C153911025 @default.
- W2974553306 hasConcept C170493617 @default.
- W2974553306 hasConcept C180754005 @default.
- W2974553306 hasConcept C2775960820 @default.
- W2974553306 hasConcept C2778993516 @default.
- W2974553306 hasConcept C54355233 @default.
- W2974553306 hasConcept C57708383 @default.
- W2974553306 hasConcept C85789140 @default.
- W2974553306 hasConcept C86803240 @default.
- W2974553306 hasConceptScore W2974553306C104317684 @default.
- W2974553306 hasConceptScore W2974553306C122871604 @default.
- W2974553306 hasConceptScore W2974553306C127716648 @default.
- W2974553306 hasConceptScore W2974553306C144174609 @default.
- W2974553306 hasConceptScore W2974553306C1491633281 @default.
- W2974553306 hasConceptScore W2974553306C150194340 @default.
- W2974553306 hasConceptScore W2974553306C153911025 @default.