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- W2974553902 abstract "In situ transgenesis methods such as viruses and electroporation can rapidly create somatic transgenic mice but lack control over copy number, zygosity, and locus specificity. Here we establish mosaic analysis by dual recombinase-mediated cassette exchange (MADR), which permits stable labeling of mutant cells expressing transgenic elements from precisely defined chromosomal loci. We provide a toolkit of MADR elements for combination labeling, inducible and reversible transgene manipulation, VCre recombinase expression, and transgenesis of human cells. Further, we demonstrate the versatility of MADR by creating glioma models with mixed reporter-identified zygosity or with “personalized” driver mutations from pediatric glioma. MADR is extensible to thousands of existing mouse lines, providing a flexible platform to democratize the generation of somatic mosaic mice.Video AbstracteyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiJlMDE2ZTc4NTYyMDc3MGQyZGRlNjk2ZDA5ODRjNTMwMCIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc4ODA2ODYxfQ.kS5EG-9tVwUmDMtbytqRbgRYuiU-U4SMeEgd8h_8Dh1cxHIICP2sp5HZZsp5siioZJSVWsbx5iPzFEYFIccfyjY9v0JJ4HIEW11KQQZcxJPGi2fssW9sdE9s-4qUA7-_YddizKfm_7nsaBalRAQM3g7VF8Afk5bBwrNO2HGu6ds9cFcdgcd8RemhpxQWtyDT6JMaE6xvObUjXOJJ4YqoHpd9fLGA0hA3c_DPRmzTFF4wJZqDZhiQieqt57d8FptZYjxmq0cprwqir2yPMX8odqI8k1kWqDrZiZu8ujOhaG6arxDn9z6sU5S3JdFeNGy7ihTQkR4vcrKoN2xDnrlB7w(mp4, (63.94 MB) Download video" @default.
- W2974553902 created "2019-09-26" @default.
- W2974553902 creator A5001498982 @default.
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- W2974553902 date "2019-09-01" @default.
- W2974553902 modified "2023-10-14" @default.
- W2974553902 title "Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements" @default.
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