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- W2974570729 abstract "Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder whose neurodevelopmental symptoms include impaired executive function, attention, and spatial learning and could be due to perturbed mesolimbic dopaminergic circuitry. However, these circuits have never been directly assayed in vivo. We employed the genetically encoded optical dopamine sensor dLight1 to monitor dopaminergic neurotransmission in the ventral striatum of NF1 mice during motivated behavior. Additionally, we developed novel systemic AAV vectors to facilitate morphological reconstruction of dopaminergic populations in cleared tissue. We found that NF1 mice exhibit reduced spontaneous dopaminergic neurotransmission that was associated with excitation/inhibition imbalance in the ventral tegmental area and abnormal neuronal morphology. NF1 mice also had more robust dopaminergic and behavioral responses to salient visual stimuli, which were independent of learning, and rescued by optogenetic inhibition of non-dopaminergic neurons in the VTA. Overall, these studies provide a first in vivo characterization of dopaminergic circuit function in the context of NF1 and reveal novel pathophysiological mechanisms." @default.
- W2974570729 created "2019-09-26" @default.
- W2974570729 creator A5010921137 @default.
- W2974570729 creator A5032137468 @default.
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- W2974570729 creator A5080490976 @default.
- W2974570729 creator A5083297631 @default.
- W2974570729 date "2019-09-23" @default.
- W2974570729 modified "2023-10-15" @default.
- W2974570729 title "Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1" @default.
- W2974570729 cites W1567873511 @default.
- W2974570729 cites W1591050868 @default.
- W2974570729 cites W1601407383 @default.
- W2974570729 cites W1602139841 @default.
- W2974570729 cites W1620979336 @default.
- W2974570729 cites W1823302046 @default.
- W2974570729 cites W1853541416 @default.
- W2974570729 cites W1875506666 @default.
- W2974570729 cites W1906859819 @default.
- W2974570729 cites W1974737922 @default.
- W2974570729 cites W1977206884 @default.
- W2974570729 cites W1977514547 @default.
- W2974570729 cites W1977654168 @default.
- W2974570729 cites W1980416511 @default.
- W2974570729 cites W1987025030 @default.
- W2974570729 cites W1997128521 @default.
- W2974570729 cites W1998939463 @default.
- W2974570729 cites W2002897878 @default.
- W2974570729 cites W2005873273 @default.
- W2974570729 cites W2007837353 @default.
- W2974570729 cites W2011200844 @default.
- W2974570729 cites W2012863406 @default.
- W2974570729 cites W2013232610 @default.
- W2974570729 cites W2014031097 @default.
- W2974570729 cites W2017835290 @default.
- W2974570729 cites W2018759485 @default.
- W2974570729 cites W2020231002 @default.
- W2974570729 cites W2031178639 @default.
- W2974570729 cites W2033263745 @default.
- W2974570729 cites W2037060024 @default.
- W2974570729 cites W2037457092 @default.
- W2974570729 cites W2041609008 @default.
- W2974570729 cites W2043682910 @default.
- W2974570729 cites W2045821490 @default.
- W2974570729 cites W2053286087 @default.
- W2974570729 cites W2055911520 @default.
- W2974570729 cites W2060210617 @default.
- W2974570729 cites W2062186304 @default.
- W2974570729 cites W2062605351 @default.
- W2974570729 cites W2071893342 @default.
- W2974570729 cites W2076457657 @default.
- W2974570729 cites W2078340953 @default.
- W2974570729 cites W2083048982 @default.
- W2974570729 cites W2083782834 @default.
- W2974570729 cites W2085449697 @default.
- W2974570729 cites W2094561611 @default.
- W2974570729 cites W2095088925 @default.
- W2974570729 cites W2097094353 @default.
- W2974570729 cites W2102027938 @default.
- W2974570729 cites W2103545875 @default.
- W2974570729 cites W2105248638 @default.
- W2974570729 cites W2106501464 @default.
- W2974570729 cites W2106718396 @default.
- W2974570729 cites W2117389654 @default.
- W2974570729 cites W2117411297 @default.
- W2974570729 cites W2118908028 @default.
- W2974570729 cites W2119368326 @default.
- W2974570729 cites W2124178069 @default.
- W2974570729 cites W2129927715 @default.
- W2974570729 cites W2130690907 @default.
- W2974570729 cites W2142011448 @default.
- W2974570729 cites W2142671349 @default.
- W2974570729 cites W2145882426 @default.
- W2974570729 cites W2149675711 @default.
- W2974570729 cites W2156581621 @default.
- W2974570729 cites W2156718767 @default.
- W2974570729 cites W2165398609 @default.
- W2974570729 cites W2259648020 @default.
- W2974570729 cites W2402721223 @default.
- W2974570729 cites W2408389305 @default.
- W2974570729 cites W2464888703 @default.
- W2974570729 cites W2538251049 @default.
- W2974570729 cites W2623791013 @default.
- W2974570729 cites W2708579841 @default.
- W2974570729 cites W2754279436 @default.
- W2974570729 cites W2789518452 @default.
- W2974570729 cites W2807588602 @default.
- W2974570729 cites W2902477192 @default.
- W2974570729 cites W2910480910 @default.
- W2974570729 cites W2950113757 @default.
- W2974570729 cites W2951967622 @default.
- W2974570729 cites W2974570729 @default.
- W2974570729 cites W3099246903 @default.
- W2974570729 cites W4211088618 @default.
- W2974570729 cites W4211179297 @default.
- W2974570729 cites W4211229214 @default.