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• W2974632743 startingPage "20063" @default.
• W2974632743 abstract "Significance MITA/STING is an essential adaptor protein for innate immune response to DNA virus or damaged cellular DNA. In this study, we identified 2 protein phosphatases, PTPN1 and PTPN2, as negative regulators of MITA/STING. After the onset of innate immune response to DNA virus, PTPN1/2 dephosphorylate MITA/STING, which subsequently causes its degradation by the ubiquitin-independent 20S proteasomes. This study reveals a striking mechanism on how innate immune response to DNA virus is attenuated and therefore would help for drug or vaccine development against DNA virus infection." @default.
• W2974632743 created "2019-09-26" @default.
• W2974632743 creator A5012470655 @default.
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• W2974632743 date "2019-09-16" @default.
• W2974632743 modified "2023-10-06" @default.
• W2974632743 title "PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response" @default.
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• W2974632743 doi "https://doi.org/10.1073/pnas.1906431116" @default.
• W2974632743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6778251" @default.
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• W2974632743 hasPublicationYear "2019" @default.
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