FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2974648859> ?p ?o ?g. }

• W2974648859 endingPage "728" @default.
• W2974648859 startingPage "728" @default.
• W2974648859 abstract "Mitochondrial nicotinamide adenine dinucleotide phosphate (NADP+)-dependent isocitrate dehydrogenase (IDH2) plays a key role in the intermediary metabolism and energy production via catalysing oxidative decarboxylation of isocitrate to α-ketoglutarate in the tricarboxylic acid (TCA) cycle. Despite studies reporting potential interlinks between IDH2 and various diseases, there is lack of effort to comprehensively characterize signature(s) of IDH2 knockout (IDH2 KO) mice. A total of 6583 transcripts were identified from both wild-type (WT) and IDH2 KO mice liver tissues. Afterwards, 167 differentially expressed genes in the IDH2 KO group were short-listed compared to the WT group based on our criteria. The online bioinformatic analyses indicated that lipid metabolism is the most significantly influenced metabolic process in IDH2 KO mice. Moreover, the TR/RXR activation pathway was predicted as the top canonical pathway significantly affected by IDH2 KO. The key transcripts found in the bioinformatic analyses were validated by qPCR analysis, corresponding to the transcriptomics results. Further, an additional qPCR analysis confirmed that IDH2 KO caused a decrease in hepatic de novo lipogenesis via the activation of the fatty acid β-oxidation process. Our unbiased transcriptomics approach and validation experiments suggested that IDH2 might play a key role in homeostasis of lipid metabolism." @default.
• W2974648859 created "2019-09-26" @default.
• W2974648859 creator A5002059544 @default.
• W2974648859 creator A5009401547 @default.
• W2974648859 creator A5025344248 @default.
• W2974648859 creator A5037924247 @default.
• W2974648859 creator A5046913527 @default.
• W2974648859 creator A5049397692 @default.
• W2974648859 creator A5065657611 @default.
• W2974648859 creator A5068793957 @default.
• W2974648859 creator A5072498585 @default.
• W2974648859 creator A5076375469 @default.
• W2974648859 creator A5077212478 @default.
• W2974648859 date "2019-09-19" @default.
• W2974648859 modified "2023-09-26" @default.
• W2974648859 title "Hepatic Transcriptomics Reveals that Lipogenesis Is a Key Signaling Pathway in Isocitrate Dehydrogenase 2 Deficient Mice" @default.
• W2974648859 cites W1738677317 @default.
• W2974648859 cites W1875102167 @default.
• W2974648859 cites W1967502002 @default.
• W2974648859 cites W1974580919 @default.
• W2974648859 cites W1982111232 @default.
• W2974648859 cites W1988364643 @default.
• W2974648859 cites W2011574523 @default.
• W2974648859 cites W2014234522 @default.
• W2974648859 cites W2017161553 @default.
• W2974648859 cites W2033436619 @default.
• W2974648859 cites W2033823674 @default.
• W2974648859 cites W2034046497 @default.
• W2974648859 cites W2035712885 @default.
• W2974648859 cites W2037636099 @default.
• W2974648859 cites W2039890062 @default.
• W2974648859 cites W2040871554 @default.
• W2974648859 cites W2054601149 @default.
• W2974648859 cites W2059642778 @default.
• W2974648859 cites W2071373998 @default.
• W2974648859 cites W2080107084 @default.
• W2974648859 cites W2087514755 @default.
• W2974648859 cites W2088929386 @default.
• W2974648859 cites W2090551990 @default.
• W2974648859 cites W2093391702 @default.
• W2974648859 cites W2101580126 @default.
• W2974648859 cites W2102940743 @default.
• W2974648859 cites W2107054031 @default.
• W2974648859 cites W2124951199 @default.
• W2974648859 cites W2128375620 @default.
• W2974648859 cites W2131960328 @default.
• W2974648859 cites W2146544786 @default.
• W2974648859 cites W2154431984 @default.
• W2974648859 cites W2157817725 @default.
• W2974648859 cites W2212083275 @default.
• W2974648859 cites W2492581465 @default.
• W2974648859 cites W2553223175 @default.
• W2974648859 cites W2572520025 @default.
• W2974648859 cites W2606939580 @default.
• W2974648859 cites W2615980933 @default.
• W2974648859 cites W2728778929 @default.
• W2974648859 cites W2751766539 @default.
• W2974648859 cites W2761245997 @default.
• W2974648859 cites W2803006699 @default.
• W2974648859 cites W2803483202 @default.
• W2974648859 cites W2803914297 @default.
• W2974648859 cites W2891009351 @default.
• W2974648859 cites W4230809943 @default.
• W2974648859 cites W4252021281 @default.
• W2974648859 doi "https://doi.org/10.3390/genes10090728" @default.
• W2974648859 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6770969" @default.
• W2974648859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31546946" @default.
• W2974648859 hasPublicationYear "2019" @default.
• W2974648859 type Work @default.
• W2974648859 sameAs 2974648859 @default.
• W2974648859 citedByCount "1" @default.
• W2974648859 countsByYear W29746488592022 @default.
• W2974648859 crossrefType "journal-article" @default.
• W2974648859 hasAuthorship W2974648859A5002059544 @default.
• W2974648859 hasAuthorship W2974648859A5009401547 @default.
• W2974648859 hasAuthorship W2974648859A5025344248 @default.
• W2974648859 hasAuthorship W2974648859A5037924247 @default.
• W2974648859 hasAuthorship W2974648859A5046913527 @default.
• W2974648859 hasAuthorship W2974648859A5049397692 @default.
• W2974648859 hasAuthorship W2974648859A5065657611 @default.
• W2974648859 hasAuthorship W2974648859A5068793957 @default.
• W2974648859 hasAuthorship W2974648859A5072498585 @default.
• W2974648859 hasAuthorship W2974648859A5076375469 @default.
• W2974648859 hasAuthorship W2974648859A5077212478 @default.
• W2974648859 hasBestOaLocation W29746488591 @default.
• W2974648859 hasConcept C104317684 @default.
• W2974648859 hasConcept C127848430 @default.
• W2974648859 hasConcept C141359234 @default.
• W2974648859 hasConcept C143065580 @default.
• W2974648859 hasConcept C150194340 @default.
• W2974648859 hasConcept C162317418 @default.
• W2974648859 hasConcept C165135838 @default.
• W2974648859 hasConcept C165267168 @default.
• W2974648859 hasConcept C181199279 @default.
• W2974648859 hasConcept C192989942 @default.
• W2974648859 hasConcept C2776059313 @default.
• W2974648859 hasConcept C2777150147 @default.
• W2974648859 hasConcept C4733338 @default.

• next