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• W2974660015 abstract "Abstract Gene loops are formed by the interaction of initiation and termination factors occupying the distal ends of a gene during transcription. RNAPII is believed to affect gene looping indirectly owing to its essential role in transcription. The results presented here, however, demonstrate a direct role of RNAPII in gene looping through the Rpb4 subunit. 3C analysis revealed that gene looping is abolished in the rpb4Δ mutant. In contrast to the other looping-defective mutants, rpb4Δ cells do not exhibit a transcription termination defect. RPB4 overexpression, however, rescued the transcription termination and gene looping defect of sua7-1, a mutant of TFIIB. Furthermore, RPB4 overexpression rescued the ssu72-2 gene looping defect, while SSU72 overexpression restored the formation of gene loops in rpb4Δ cells. Interestingly, the interaction of TFIIB with Ssu72 is compromised in rpb4Δ cells. These results suggest that the TFIIB–Ssu72 interaction, which is critical for gene loop formation, is facilitated by Rpb4. We propose that Rpb4 is promoting the transfer of RNAPII from the terminator to the promoter for reinitiation of transcription through TFIIB–Ssu72 mediated gene looping." @default.
• W2974660015 created "2019-09-26" @default.
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• W2974660015 date "2019-07-15" @default.
• W2974660015 modified "2023-10-15" @default.
• W2974660015 title "RNA polymerase II plays an active role in the formation of gene loops through the Rpb4 subunit" @default.
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• W2974660015 doi "https://doi.org/10.1093/nar/gkz597" @default.
• W2974660015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6753479" @default.
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