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- W2974667023 abstract "Enormous progress in understanding the mechanisms that mediate pain can be augmented by an evolutionary medicine perspective on how the capacity for pain gives selective advantages, the trade-offs that shaped the mechanisms, and evolutionary explanations for the system's vulnerability to excessive and chronic pain. Syndromes of deficient pain document tragically the utility of pain to motivate escape from and avoidance of situations causing tissue damage. Much apparently excessive pain is actually normal because the cost of more pain is often vastly less than the cost of too little pain (the smoke detector principle). Vulnerability to pathological pain may be explained in part because natural selection has shaped mechanisms that respond adaptively to repeated tissue damage by decreasing the pain threshold and increasing pain salience. The other half of an evolutionary approach describes the phylogeny of pain mechanisms; the apparent independence of different kinds of pain is of special interest. Painful mental states such as anxiety, guilt and low mood may have evolved from physical pain precursors. Preliminary evidence for this is found in anatomic and genetic data. Such insights from evolutionary medicine may help in understanding vulnerability to chronic pain. This article is part of the Theo Murphy meeting issue ‘Evolution of mechanisms and behaviour important for pain’." @default.
- W2974667023 created "2019-09-26" @default.
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- W2974667023 date "2019-09-23" @default.
- W2974667023 modified "2023-10-16" @default.
- W2974667023 title "An evolutionary medicine perspective on pain and its disorders" @default.
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- W2974667023 doi "https://doi.org/10.1098/rstb.2019.0288" @default.
- W2974667023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6790386" @default.
- W2974667023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31544605" @default.
- W2974667023 hasPublicationYear "2019" @default.
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