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- W2974672973 endingPage "535" @default.
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- W2974672973 abstract "The detection of borderline oxacillin-resistant Staphylococcus aureus (BORSA) represents a challenge to both, veterinary and human laboratories. Between 2015 and 2017, 19 equine S. aureus with elevated minimal inhibitory concentrations for oxacillin were detected in routine diagnostics. The aim of this study was to characterize these isolates to identify factors possibly associated with the BORSA phenotype. All S. aureus were subjected to antimicrobial susceptibility testing and whole genome sequencing (WGS). A quantifiable β-lactamase activity assay was performed for a representative subset of 13 isolates. The WGS data analysis of the 19 BORSA isolates identified two different genomic lineages, sequence type (ST) 1 and ST1660. The core genome multilocus sequence typing (cgMLST) revealed a close relatedness of all isolates belonging to either ST1 or ST1660. The WGS analysis identified the resistance genes aadD, dfrG, tet(L), and/or blaZ and aacA-aphD. Phenotypic resistance to penicillins, aminoglycosides, tetracyclines, fluoroquinolones and sulfamethoxazole/trimethoprim was observed in the respective isolates. For the penicillin-binding proteins 1–4, amino acid substitutions were predicted using WGS data. Since neither transglycosylase nor transpeptidase domains were affected, these alterations might not explain the BORSA phenotype. Moreover, β-lactamase activity was found to be associated with an inducible blaZ gene. The lineage-specific differences regarding the expression profiles were noted." @default.
- W2974672973 created "2019-09-26" @default.
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- W2974672973 date "2019-09-13" @default.
- W2974672973 modified "2023-09-29" @default.
- W2974672973 title "Molecular Characterization of Equine Staphylococcus aureus Isolates Exhibiting Reduced Oxacillin Susceptibility" @default.
- W2974672973 cites W1878404532 @default.
- W2974672973 cites W1908455897 @default.
- W2974672973 cites W1909470475 @default.
- W2974672973 cites W1967150038 @default.
- W2974672973 cites W1980677641 @default.
- W2974672973 cites W1994576782 @default.
- W2974672973 cites W1995192717 @default.
- W2974672973 cites W1998713625 @default.
- W2974672973 cites W2000140271 @default.
- W2974672973 cites W2004237056 @default.
- W2974672973 cites W2004548026 @default.
- W2974672973 cites W2013333290 @default.
- W2974672973 cites W2030390297 @default.
- W2974672973 cites W2033817452 @default.
- W2974672973 cites W2042010250 @default.
- W2974672973 cites W2044124840 @default.
- W2974672973 cites W2054504313 @default.
- W2974672973 cites W2055043387 @default.
- W2974672973 cites W2059555686 @default.
- W2974672973 cites W2068627300 @default.
- W2974672973 cites W2070715756 @default.
- W2974672973 cites W2075858654 @default.
- W2974672973 cites W2084417263 @default.
- W2974672973 cites W2085927992 @default.
- W2974672973 cites W2096093282 @default.
- W2974672973 cites W2101610216 @default.
- W2974672973 cites W2103995886 @default.
- W2974672973 cites W2105999876 @default.
- W2974672973 cites W2109129901 @default.
- W2974672973 cites W2111516721 @default.
- W2974672973 cites W2115119951 @default.
- W2974672973 cites W2116279310 @default.
- W2974672973 cites W2118581886 @default.
- W2974672973 cites W2119699028 @default.
- W2974672973 cites W2121720973 @default.
- W2974672973 cites W2134852597 @default.
- W2974672973 cites W2140046792 @default.
- W2974672973 cites W2152544358 @default.
- W2974672973 cites W2160467552 @default.
- W2974672973 cites W2162124867 @default.
- W2974672973 cites W2169174113 @default.
- W2974672973 cites W2207855041 @default.
- W2974672973 cites W2228631111 @default.
- W2974672973 cites W2274965335 @default.
- W2974672973 cites W2275498402 @default.
- W2974672973 cites W2346904432 @default.
- W2974672973 cites W2470023868 @default.
- W2974672973 cites W2555859910 @default.
- W2974672973 cites W2572566025 @default.
- W2974672973 cites W2598354970 @default.
- W2974672973 cites W2606725433 @default.
- W2974672973 cites W2629080863 @default.
- W2974672973 cites W2738154249 @default.
- W2974672973 cites W2754660043 @default.
- W2974672973 cites W2762058660 @default.
- W2974672973 cites W2767878556 @default.
- W2974672973 cites W2781599883 @default.
- W2974672973 cites W2789520806 @default.
- W2974672973 cites W2789612266 @default.
- W2974672973 cites W2792458579 @default.
- W2974672973 cites W2802235059 @default.
- W2974672973 cites W2802590676 @default.
- W2974672973 cites W2802760993 @default.
- W2974672973 cites W2806290899 @default.
- W2974672973 cites W2808857036 @default.
- W2974672973 cites W2847838470 @default.
- W2974672973 cites W2891514665 @default.
- W2974672973 cites W2893009276 @default.
- W2974672973 cites W2893110909 @default.
- W2974672973 cites W2895280009 @default.
- W2974672973 cites W2898083932 @default.
- W2974672973 cites W2898355146 @default.
- W2974672973 cites W2899065326 @default.
- W2974672973 cites W2900501296 @default.
- W2974672973 cites W2912076341 @default.
- W2974672973 cites W2912746983 @default.
- W2974672973 cites W2914408460 @default.
- W2974672973 cites W2925564220 @default.
- W2974672973 cites W2937429929 @default.
- W2974672973 cites W2951154451 @default.
- W2974672973 doi "https://doi.org/10.3390/toxins11090535" @default.
- W2974672973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6783909" @default.
- W2974672973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31540335" @default.