FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2974686296> ?p ?o ?g. }

• W2974686296 endingPage "111626" @default.
• W2974686296 startingPage "111626" @default.
• W2974686296 abstract "Liver Cholestasis is a widespread disease of broad etiologies and ultimately results in fibrosis, which is still lacking effective therapeutic strategies. Activation of hepatic stellate cells (HSCs) is the key event of liver fibrosis. Here, we aimed to investigate the effect and mechanism of the Slit2 signaling in cholestasis-induced liver fibrosis. Our findings revealed that the serum levels and hepatic expression of Slit2 were significantly increased in patients with primary biliary cirrhosis (PBC). Additionally, Slit2-Tg mice were much more vulnerable to BDL-induced liver injury and fibrosis compared to WT control. Slit2 up-regulation by Slit2 recombinant protein induced proliferation, and inhibited apoptosis of human HSCs cell line LX-2 via p38 and ERK signaling pathway, resulting in the activation of HSCs. In contrast, Slit2 down-regulation by siRNA silencing inhibit the activation of HSCs. In conclusion, Slit2 is involved in the activation of HSCs and liver fibrogenesis, highlighting Slit2 as a potential therapeutic target for liver fibrosis." @default.
• W2974686296 created "2019-09-26" @default.
• W2974686296 creator A5001906823 @default.
• W2974686296 creator A5013559447 @default.
• W2974686296 creator A5013578775 @default.
• W2974686296 creator A5025360612 @default.
• W2974686296 creator A5038449262 @default.
• W2974686296 creator A5039383725 @default.
• W2974686296 creator A5042346178 @default.
• W2974686296 creator A5081435176 @default.
• W2974686296 creator A5088035338 @default.
• W2974686296 date "2019-12-01" @default.
• W2974686296 modified "2023-10-16" @default.
• W2974686296 title "Slit2 signaling contributes to cholestatic fibrosis in mice by activation of hepatic stellate cells" @default.
• W2974686296 cites W1444331719 @default.
• W2974686296 cites W1965588383 @default.
• W2974686296 cites W1991049147 @default.
• W2974686296 cites W1996405087 @default.
• W2974686296 cites W1997356351 @default.
• W2974686296 cites W2024040797 @default.
• W2974686296 cites W2026308186 @default.
• W2974686296 cites W2030907940 @default.
• W2974686296 cites W2047370624 @default.
• W2974686296 cites W2058667428 @default.
• W2974686296 cites W2059570252 @default.
• W2974686296 cites W2062289724 @default.
• W2974686296 cites W2075781716 @default.
• W2974686296 cites W2083410657 @default.
• W2974686296 cites W2083915878 @default.
• W2974686296 cites W2084964460 @default.
• W2974686296 cites W2109909380 @default.
• W2974686296 cites W2123561714 @default.
• W2974686296 cites W2135086805 @default.
• W2974686296 cites W2143407490 @default.
• W2974686296 cites W2162439940 @default.
• W2974686296 cites W2170004041 @default.
• W2974686296 cites W2195744714 @default.
• W2974686296 cites W2327522408 @default.
• W2974686296 cites W2512421145 @default.
• W2974686296 cites W2602684234 @default.
• W2974686296 cites W2607280581 @default.
• W2974686296 cites W2735941768 @default.
• W2974686296 cites W2746014752 @default.
• W2974686296 cites W2748370651 @default.
• W2974686296 cites W2921100812 @default.
• W2974686296 cites W4255712601 @default.
• W2974686296 doi "https://doi.org/10.1016/j.yexcr.2019.111626" @default.
• W2974686296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31545977" @default.
• W2974686296 hasPublicationYear "2019" @default.
• W2974686296 type Work @default.
• W2974686296 sameAs 2974686296 @default.
• W2974686296 citedByCount "8" @default.
• W2974686296 countsByYear W29746862962020 @default.
• W2974686296 countsByYear W29746862962021 @default.
• W2974686296 countsByYear W29746862962022 @default.
• W2974686296 countsByYear W29746862962023 @default.
• W2974686296 crossrefType "journal-article" @default.
• W2974686296 hasAuthorship W2974686296A5001906823 @default.
• W2974686296 hasAuthorship W2974686296A5013559447 @default.
• W2974686296 hasAuthorship W2974686296A5013578775 @default.
• W2974686296 hasAuthorship W2974686296A5025360612 @default.
• W2974686296 hasAuthorship W2974686296A5038449262 @default.
• W2974686296 hasAuthorship W2974686296A5039383725 @default.
• W2974686296 hasAuthorship W2974686296A5042346178 @default.
• W2974686296 hasAuthorship W2974686296A5081435176 @default.
• W2974686296 hasAuthorship W2974686296A5088035338 @default.
• W2974686296 hasConcept C104317684 @default.
• W2974686296 hasConcept C119056186 @default.
• W2974686296 hasConcept C126322002 @default.
• W2974686296 hasConcept C134018914 @default.
• W2974686296 hasConcept C176891718 @default.
• W2974686296 hasConcept C190283241 @default.
• W2974686296 hasConcept C203014093 @default.
• W2974686296 hasConcept C2776637226 @default.
• W2974686296 hasConcept C2777214474 @default.
• W2974686296 hasConcept C2778593092 @default.
• W2974686296 hasConcept C2780366471 @default.
• W2974686296 hasConcept C2780559512 @default.
• W2974686296 hasConcept C2993667909 @default.
• W2974686296 hasConcept C502942594 @default.
• W2974686296 hasConcept C55493867 @default.
• W2974686296 hasConcept C57074206 @default.
• W2974686296 hasConcept C62478195 @default.
• W2974686296 hasConcept C71924100 @default.
• W2974686296 hasConcept C86803240 @default.
• W2974686296 hasConcept C95444343 @default.
• W2974686296 hasConceptScore W2974686296C104317684 @default.
• W2974686296 hasConceptScore W2974686296C119056186 @default.
• W2974686296 hasConceptScore W2974686296C126322002 @default.
• W2974686296 hasConceptScore W2974686296C134018914 @default.
• W2974686296 hasConceptScore W2974686296C176891718 @default.
• W2974686296 hasConceptScore W2974686296C190283241 @default.
• W2974686296 hasConceptScore W2974686296C203014093 @default.
• W2974686296 hasConceptScore W2974686296C2776637226 @default.
• W2974686296 hasConceptScore W2974686296C2777214474 @default.
• W2974686296 hasConceptScore W2974686296C2778593092 @default.
• W2974686296 hasConceptScore W2974686296C2780366471 @default.
• W2974686296 hasConceptScore W2974686296C2780559512 @default.

• next