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- W2974703120 abstract "Abstract Exposure to high temperatures is known to impair immune functions and disease resistance of poultry. Characterizing changes in the transcriptome can help identify mechanisms by which immune tissues, such as the thymus, respond to heat stress. In this study, 22-day-old chickens from two genetic lines (a relatively resistant Fayoumi line and a more susceptible broiler line) were exposed to acute heat stress (35 °C) and/or immune simulation with lipopolysaccharide (LPS; 100 µg/kg). Transcriptome responses in the thymus were identified by RNA-sequencing (RNA-seq). Expression of most genes was unaffected by heat and/or LPS in the Fayoumi line, whereas these treatments had more impact in the broiler line. Comparisons between the broiler and Fayoumi transcriptomes identified a large number of significant genes both at homeostasis and in response to treatment. Functional analyses predicted that gene expression changes impact immune responses, apoptosis, cell activation, migration, and adhesion. In broilers, acute heat stress changed thymic expression responses to LPS and could impact thymocyte survival and trafficking, and thereby contribute to the negative effects of high temperatures on immune responses. Identification of these genes and pathways provides a foundation for testing targets to improve disease resistance in heat-stressed chickens." @default.
- W2974703120 created "2019-09-26" @default.
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- W2974703120 date "2019-09-20" @default.
- W2974703120 modified "2023-10-15" @default.
- W2974703120 title "Genetic lines respond uniquely within the chicken thymic transcriptome to acute heat stress and low dose lipopolysaccharide" @default.
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- W2974703120 cites W1968684496 @default.
- W2974703120 cites W1977036651 @default.
- W2974703120 cites W1978084874 @default.
- W2974703120 cites W1980987471 @default.
- W2974703120 cites W1983833939 @default.
- W2974703120 cites W1993983321 @default.
- W2974703120 cites W2006456631 @default.
- W2974703120 cites W2015197564 @default.
- W2974703120 cites W2016525655 @default.
- W2974703120 cites W2021998414 @default.
- W2974703120 cites W2023142178 @default.
- W2974703120 cites W2029677015 @default.
- W2974703120 cites W2029884260 @default.
- W2974703120 cites W2057476376 @default.
- W2974703120 cites W2061266998 @default.
- W2974703120 cites W2064358808 @default.
- W2974703120 cites W2070015571 @default.
- W2974703120 cites W2071535279 @default.
- W2974703120 cites W2078132464 @default.
- W2974703120 cites W2083475160 @default.
- W2974703120 cites W2086453496 @default.
- W2974703120 cites W2097745021 @default.
- W2974703120 cites W2098816092 @default.
- W2974703120 cites W2101101443 @default.
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- W2974703120 cites W2111034570 @default.
- W2974703120 cites W2129628305 @default.
- W2974703120 cites W2131271579 @default.
- W2974703120 cites W2131459545 @default.
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- W2974703120 cites W2134526812 @default.
- W2974703120 cites W2135286058 @default.
- W2974703120 cites W2136170412 @default.
- W2974703120 cites W2144640346 @default.
- W2974703120 cites W2154301658 @default.
- W2974703120 cites W2162921274 @default.
- W2974703120 cites W2165422594 @default.
- W2974703120 cites W2169456326 @default.
- W2974703120 cites W2169683728 @default.
- W2974703120 cites W2179438025 @default.
- W2974703120 cites W2182422457 @default.
- W2974703120 cites W2196577623 @default.
- W2974703120 cites W2263724510 @default.
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- W2974703120 cites W2346922468 @default.
- W2974703120 cites W2489356553 @default.
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- W2974703120 cites W2559466477 @default.
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- W2974703120 cites W2587345915 @default.
- W2974703120 cites W2591867868 @default.
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- W2974703120 cites W2739926192 @default.
- W2974703120 cites W2753951398 @default.
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- W2974703120 doi "https://doi.org/10.1038/s41598-019-50051-0" @default.
- W2974703120 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6754502" @default.
- W2974703120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31541148" @default.
- W2974703120 hasPublicationYear "2019" @default.
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