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- W2974713838 abstract "Traditional medicine has a holistic approach to the treatment of a disease, and consequently, many herbal mixtures, intended for the treatment of both primary and secondary diabetes complications, are available. One of the most commonly used in Europe, primarily in the Balkan countries, is made of blackberry (Rubus fruticosus L., Rosaceae) leaves, blueberry (Vaccinium myrtillus L., Ericaceae) leaves, tormentil (Potentilla erecta (L.) Rauschel, Rosaceae) roots, St. Benedict's herb (Geum urbanum L., Rosaceae) aerial parts, and kidney bean (Phaseolus vulgaris L., Fabaceae) pods. The aim of this study was to evaluate the potential of “anti-diabetic” herbal mixture as well as its constituents to counter-react secondary diabetic complications caused by extensive production of reactive oxygen species (ROS) and constant hyperglycemia environment, as well as to assess their potential cyto-/genotoxic properties. Possible cyto-/genotoxic effects of tested extracts, as well as their anticyto-/antigenotoxic effect against H2O2-induced genetic damage, were evaluated using the A. cepa assay. The results obtained via A. cepa test were compared with those obtained in the RBCs antihemolytic test. Antimicrobial activity was assessed using a broth microdilution method (MIC) against 6 bacterial and 1 fungal strain. The extracts were prepared according to the traditional use, i.e. decoction. The study revealed that all the tested decoctions, based on the used concentration, can act both as free-radical scavengers or free-radical producers. Most of the tested samples in the cyto-/genotoxicity A. cepa test have shown only a mild cytotoxic effect, but some of them have acted as strong genotoxic agents. The highest genotoxic potential had P. vulgaris and V. myrtillus decoctions when used in high concentrations (1200 μg/ml). The lowest cytotoxic and genotoxic effect on A. cepa meristematic cells had the decoction of “anti-diabetic” herbal preparation. In the antigenotoxicity A. cepa test, all tested extracts had the capacity to reverse chromosomal aberrations, and the highest antioxidant activity had “anti-diabetic” herbal mixture (45 and 70 μg/ml) and P. vulgaris (70 μg/ml). Results obtained from the RBCs antihemolytic experiment were similar to the results of the A. cepa test. All the extracts in lower concentrations, i.e. 25, 50 and 100 μg/ml had strong antihemolytic activity, implying on their protective activity against cell damage caused by ROS. Except of P. erecta decoction, all the other tested decoctions had only mild antimicrobial and/or antifungal activities. Interestingly, even low concentrations of the herbal mixture have shown higher efficiency in both the capturing of free radicals and the repair of the already damaged genetic material, compared to its ingredients when used alone, and at the same time, this mixture was relatively safe even when used in higher doses. The safest use of these medicinal plants is when used together, in a precisely defined recipe." @default.
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- W2974713838 date "2019-07-01" @default.
- W2974713838 modified "2023-09-27" @default.
- W2974713838 title "Genotoxic and antigenotoxic potential of “anti-diabetic” herbal preparation and five medicinal plants – A. cepa test" @default.
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