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• W2974755263 endingPage "19.2019" @default.
• W2974755263 startingPage "ENEURO.0318" @default.
• W2974755263 abstract "Abstract The social environment influences neurodevelopment. Investigations using rodents to study this phenomenon commonly isolate subjects, then assess neurobehavioral consequences while animals are still isolated. This approach precludes one from dissociating the effects of on-going versus prior isolation, hindering our complete understanding of the consequences of social experience during particular developmental periods. Here, we socially isolated adolescent mice from postnatal day (P)31 to P60, then re-housed them into social groups. We tested their ability to select actions based on expected outcomes using multiple reinforcer devaluation and instrumental contingency degradation techniques. Social isolation in adolescence (but not adulthood) weakened instrumental response updating, causing mice to defer to habit-like behaviors. Habit biases were associated with glucocorticoid insufficiency in adolescence, oligodendrocyte marker loss throughout cortico-striatal regions, and dendritic spine and synaptic marker excess in the adult orbitofrontal cortex (OFC). Artificial, chemogenetic stimulation of the ventrolateral OFC in typical, healthy mice recapitulated response biases following isolation, causing habit-like behaviors. Meanwhile, correcting dendritic architecture by inhibiting the cytoskeletal regulatory protein ROCK remedied instrumental response updating defects in socially isolated mice. Our findings suggest that adolescence is a critical period during which social experience optimizes one’s ability to seek and attain goals later in life. Age-typical dendritic spine elimination appears to be an essential factor, and in its absence, organisms may defer to habit-based behaviors." @default.
• W2974755263 created "2019-09-26" @default.
• W2974755263 creator A5029036541 @default.
• W2974755263 creator A5046111843 @default.
• W2974755263 creator A5062045407 @default.
• W2974755263 creator A5086272159 @default.
• W2974755263 date "2019-09-01" @default.
• W2974755263 modified "2023-10-14" @default.
• W2974755263 title "Social Isolation in Adolescence Disrupts Cortical Development and Goal-Dependent Decision-Making in Adulthood, Despite Social Reintegration" @default.
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• W2974755263 doi "https://doi.org/10.1523/eneuro.0318-19.2019" @default.
• W2974755263 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6757188" @default.
• W2974755263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31527057" @default.
• W2974755263 hasPublicationYear "2019" @default.
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