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- W2974777912 abstract "This work describes the synthesis of seven new sulfonyl hydrazones, which were proposed from the general structure of acyl hydrazones and 2,4-dinitrosulfonamides. Sulfonyl hydrazones are a class of compounds known to exhibit a wide range of biological activity. In this sense, the study of the pharmacokinetic properties of the bioactive molecules is of extreme importance; therefore, in this article the permeability of these compounds with in vitro PAMPA assay mimetizing the permeability through the gastrointestinal tract as well as lipophilicity through miLogP was investigated. All compounds presented good permeability results; it was possible to make a structure-activity relationship with the obtained results and a comparison between the results." @default.
- W2974777912 created "2019-09-26" @default.
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- W2974777912 date "2019-01-01" @default.
- W2974777912 modified "2023-09-30" @default.
- W2974777912 title "Synthesis and PAMPA Permeability Assay of New Sulfonyl Hydrazone Derivatives" @default.
- W2974777912 doi "https://doi.org/10.4236/jbm.2019.79010" @default.
- W2974777912 hasPublicationYear "2019" @default.
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