FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2974787674> ?p ?o ?g. }

• W2974787674 abstract "Disturbances in cholesterol homeostasis of the bile duct epithelium, including transport interruption and the hyperaccumulation of intracellular cholesterol can lead to the initiation and progression of cholangiocarcinoma (CCA). Statins, which are lipid-lowering drugs, have been previously documented to exhibit anti-cancer properties. The role of statins in CCA cell cholesterol transport through the expression and function of ATP-binding cassette (ABC) A1 and ABCG1 was investigated in the current study. In four CCA cell lines, ABCA1 and ABCG1 expression was identified. However, neither ABCG5 nor ABCG8 expression was observed. Immunocytochemistry revealed that the expression of ABCA1 was localized in the proximity of the nucleus, while ABCG1 was more dispersed throughout the cytoplasm of KKU-100 cells. A cholesterol efflux assay was performed using bodipy cholesterol, and the translocation of cholesterol via ABCA1 and ABCG1 to Apo-A1 and high density lipoprotein was confirmed, respectively. Simvastatin and atorvastatin demonstrated the inhibitory effects on CCA cell viability. A reduction in intracellular lipid level and a lower expression of ABCA1 and ABCG1 were observed in KKU-100 cells under simvastatin treatment. The pre-exposure of KKU-100 cells to cholesterol diminished the statin effect. Furthermore, when KKU-100 cells were pre-loaded with cholesterol, ABCA1 and ABCG1-mediated exports were unaffected even though they were treated with simvastatin. The results of the current study indicated the limitations of the use of statin in CCA therapy, particularly under hypercholesterolemia conditions." @default.
• W2974787674 created "2019-09-26" @default.
• W2974787674 creator A5014225864 @default.
• W2974787674 creator A5031840950 @default.
• W2974787674 creator A5039813640 @default.
• W2974787674 creator A5045154271 @default.
• W2974787674 creator A5089821000 @default.
• W2974787674 date "2019-09-17" @default.
• W2974787674 modified "2023-09-27" @default.
• W2974787674 title "Downregulation of ABCA1 and ABCG1 transporters by simvastatin in cholangiocarcinoma cells" @default.
• W2974787674 cites W1529695053 @default.
• W2974787674 cites W1540556705 @default.
• W2974787674 cites W1542825229 @default.
• W2974787674 cites W182201473 @default.
• W2974787674 cites W1964285581 @default.
• W2974787674 cites W1964917334 @default.
• W2974787674 cites W1984792991 @default.
• W2974787674 cites W1996168740 @default.
• W2974787674 cites W2004021162 @default.
• W2974787674 cites W2012369608 @default.
• W2974787674 cites W2012604052 @default.
• W2974787674 cites W2013831157 @default.
• W2974787674 cites W2016417332 @default.
• W2974787674 cites W2018923286 @default.
• W2974787674 cites W2018944426 @default.
• W2974787674 cites W2021926309 @default.
• W2974787674 cites W2025165872 @default.
• W2974787674 cites W2025988749 @default.
• W2974787674 cites W2026823176 @default.
• W2974787674 cites W2031700740 @default.
• W2974787674 cites W2049417525 @default.
• W2974787674 cites W2050172700 @default.
• W2974787674 cites W2051765493 @default.
• W2974787674 cites W2062159116 @default.
• W2974787674 cites W2063706408 @default.
• W2974787674 cites W2065838545 @default.
• W2974787674 cites W2066456730 @default.
• W2974787674 cites W2072433515 @default.
• W2974787674 cites W2077491298 @default.
• W2974787674 cites W2084440537 @default.
• W2974787674 cites W2085775776 @default.
• W2974787674 cites W2086686877 @default.
• W2974787674 cites W2090241375 @default.
• W2974787674 cites W2093418271 @default.
• W2974787674 cites W2100491595 @default.
• W2974787674 cites W2104399391 @default.
• W2974787674 cites W2107652148 @default.
• W2974787674 cites W2107841008 @default.
• W2974787674 cites W2108300301 @default.
• W2974787674 cites W2121076428 @default.
• W2974787674 cites W2127949914 @default.
• W2974787674 cites W2131246886 @default.
• W2974787674 cites W2132160374 @default.
• W2974787674 cites W2132681796 @default.
• W2974787674 cites W2145357526 @default.
• W2974787674 cites W2164019843 @default.
• W2974787674 cites W2171996591 @default.
• W2974787674 cites W2314360011 @default.
• W2974787674 cites W2343810455 @default.
• W2974787674 cites W2345348402 @default.
• W2974787674 cites W2603993822 @default.
• W2974787674 cites W2608594977 @default.
• W2974787674 cites W2789384672 @default.
• W2974787674 cites W4231953333 @default.
• W2974787674 doi "https://doi.org/10.3892/ol.2019.10874" @default.
• W2974787674 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6781495" @default.
• W2974787674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31612028" @default.
• W2974787674 hasPublicationYear "2019" @default.
• W2974787674 type Work @default.
• W2974787674 sameAs 2974787674 @default.
• W2974787674 citedByCount "6" @default.
• W2974787674 countsByYear W29747876742020 @default.
• W2974787674 countsByYear W29747876742021 @default.
• W2974787674 crossrefType "journal-article" @default.
• W2974787674 hasAuthorship W2974787674A5014225864 @default.
• W2974787674 hasAuthorship W2974787674A5031840950 @default.
• W2974787674 hasAuthorship W2974787674A5039813640 @default.
• W2974787674 hasAuthorship W2974787674A5045154271 @default.
• W2974787674 hasAuthorship W2974787674A5089821000 @default.
• W2974787674 hasBestOaLocation W29747876741 @default.
• W2974787674 hasConcept C104317684 @default.
• W2974787674 hasConcept C110459506 @default.
• W2974787674 hasConcept C126322002 @default.
• W2974787674 hasConcept C134018914 @default.
• W2974787674 hasConcept C149011108 @default.
• W2974787674 hasConcept C185592680 @default.
• W2974787674 hasConcept C2776329913 @default.
• W2974787674 hasConcept C2776330080 @default.
• W2974787674 hasConcept C2776839432 @default.
• W2974787674 hasConcept C2777482532 @default.
• W2974787674 hasConcept C2777704780 @default.
• W2974787674 hasConcept C2778163477 @default.
• W2974787674 hasConcept C2780072125 @default.
• W2974787674 hasConcept C502942594 @default.
• W2974787674 hasConcept C55493867 @default.
• W2974787674 hasConcept C71924100 @default.
• W2974787674 hasConcept C86803240 @default.
• W2974787674 hasConcept C95444343 @default.
• W2974787674 hasConceptScore W2974787674C104317684 @default.
• W2974787674 hasConceptScore W2974787674C110459506 @default.

• next