FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2974898762> ?p ?o ?g. }

• W2974898762 abstract "Development of biocompatible and biodegradable nanocarriers with multiple functionalities has attracted great interest in recent years. In this study, a hybrid hydrogel nanoparticle (nanogel) platform based on the self-assembly of carboxymethyl cellulose (CMC) and bovine serum albumin (BSA) is presented for the first time. It was facile to realize the efficient co-delivery of radionuclide ¹³¹I and chemotherapeutic drugs such as camptothecin (CPT) to achieve the combined chemo-radioisotope therapy of cancer. Notably, a nanogel was prepared by a simple and green electrostatic interaction approach, instead of chemical reaction, showing typical spherical shape with average size about 120 nm, high drug loading capacity, robust stability and low hemolysis. Interestingly, such nanogels exhibited pH-dependent drug release profile, leading to significant reduction of damage to normal tissues. Furthermore, the as-prepared nanogels could effectively promote intracellular uptake, prolong blood circulation time and enhance accumulation in the tumor tissues. As a result, an excellent therapeutic effect was achieved both in vitro and in vivo through combined chemo-radioisotope therapy. Collectively, this study presents the preparation of a novel green nanocarrier by a reliable and simple approach, and offers an effective strategy for the combination of chemotherapy and radiotherapy." @default.
• W2974898762 created "2019-09-26" @default.
• W2974898762 creator A5023979600 @default.
• W2974898762 creator A5031245030 @default.
• W2974898762 creator A5038102178 @default.
• W2974898762 creator A5038573440 @default.
• W2974898762 creator A5056517955 @default.
• W2974898762 creator A5066895846 @default.
• W2974898762 creator A5070372051 @default.
• W2974898762 creator A5072765673 @default.
• W2974898762 date "2018-01-01" @default.
• W2974898762 modified "2023-09-23" @default.
• W2974898762 title "pH-Sensitive nanogels based on the electrostatic self-assembly of radionuclide ¹³¹I labeled albumin and carboxymethyl cellulose for synergistic combined chemo-radioisotope therapy of cancer" @default.
• W2974898762 hasPublicationYear "2018" @default.
• W2974898762 type Work @default.
• W2974898762 sameAs 2974898762 @default.
• W2974898762 citedByCount "0" @default.
• W2974898762 crossrefType "journal-article" @default.
• W2974898762 hasAuthorship W2974898762A5023979600 @default.
• W2974898762 hasAuthorship W2974898762A5031245030 @default.
• W2974898762 hasAuthorship W2974898762A5038102178 @default.
• W2974898762 hasAuthorship W2974898762A5038573440 @default.
• W2974898762 hasAuthorship W2974898762A5056517955 @default.
• W2974898762 hasAuthorship W2974898762A5066895846 @default.
• W2974898762 hasAuthorship W2974898762A5070372051 @default.
• W2974898762 hasAuthorship W2974898762A5072765673 @default.
• W2974898762 hasConcept C121608353 @default.
• W2974898762 hasConcept C12554922 @default.
• W2974898762 hasConcept C126322002 @default.
• W2974898762 hasConcept C134424308 @default.
• W2974898762 hasConcept C150903083 @default.
• W2974898762 hasConcept C171250308 @default.
• W2974898762 hasConcept C178790620 @default.
• W2974898762 hasConcept C18150654 @default.
• W2974898762 hasConcept C185592680 @default.
• W2974898762 hasConcept C192562407 @default.
• W2974898762 hasConcept C203014093 @default.
• W2974898762 hasConcept C207001950 @default.
• W2974898762 hasConcept C2776081644 @default.
• W2974898762 hasConcept C2777292972 @default.
• W2974898762 hasConcept C2777968448 @default.
• W2974898762 hasConcept C2779251873 @default.
• W2974898762 hasConcept C2779682216 @default.
• W2974898762 hasConcept C2779820397 @default.
• W2974898762 hasConcept C2779902561 @default.
• W2974898762 hasConcept C537181965 @default.
• W2974898762 hasConcept C55493867 @default.
• W2974898762 hasConcept C71924100 @default.
• W2974898762 hasConcept C86803240 @default.
• W2974898762 hasConcept C86807702 @default.
• W2974898762 hasConceptScore W2974898762C121608353 @default.
• W2974898762 hasConceptScore W2974898762C12554922 @default.
• W2974898762 hasConceptScore W2974898762C126322002 @default.
• W2974898762 hasConceptScore W2974898762C134424308 @default.
• W2974898762 hasConceptScore W2974898762C150903083 @default.
• W2974898762 hasConceptScore W2974898762C171250308 @default.
• W2974898762 hasConceptScore W2974898762C178790620 @default.
• W2974898762 hasConceptScore W2974898762C18150654 @default.
• W2974898762 hasConceptScore W2974898762C185592680 @default.
• W2974898762 hasConceptScore W2974898762C192562407 @default.
• W2974898762 hasConceptScore W2974898762C203014093 @default.
• W2974898762 hasConceptScore W2974898762C207001950 @default.
• W2974898762 hasConceptScore W2974898762C2776081644 @default.
• W2974898762 hasConceptScore W2974898762C2777292972 @default.
• W2974898762 hasConceptScore W2974898762C2777968448 @default.
• W2974898762 hasConceptScore W2974898762C2779251873 @default.
• W2974898762 hasConceptScore W2974898762C2779682216 @default.
• W2974898762 hasConceptScore W2974898762C2779820397 @default.
• W2974898762 hasConceptScore W2974898762C2779902561 @default.
• W2974898762 hasConceptScore W2974898762C537181965 @default.
• W2974898762 hasConceptScore W2974898762C55493867 @default.
• W2974898762 hasConceptScore W2974898762C71924100 @default.
• W2974898762 hasConceptScore W2974898762C86803240 @default.
• W2974898762 hasConceptScore W2974898762C86807702 @default.
• W2974898762 hasLocation W29748987621 @default.
• W2974898762 hasOpenAccess W2974898762 @default.
• W2974898762 hasPrimaryLocation W29748987621 @default.
• W2974898762 hasRelatedWork W1828382268 @default.
• W2974898762 hasRelatedWork W2095789928 @default.
• W2974898762 hasRelatedWork W2127038679 @default.
• W2974898762 hasRelatedWork W2133619272 @default.
• W2974898762 hasRelatedWork W2490222685 @default.
• W2974898762 hasRelatedWork W2555164889 @default.
• W2974898762 hasRelatedWork W2600862627 @default.
• W2974898762 hasRelatedWork W2619576841 @default.
• W2974898762 hasRelatedWork W2724472706 @default.
• W2974898762 hasRelatedWork W2807780510 @default.
• W2974898762 hasRelatedWork W2901705846 @default.
• W2974898762 hasRelatedWork W2909929552 @default.
• W2974898762 hasRelatedWork W2917195107 @default.
• W2974898762 hasRelatedWork W2924181235 @default.
• W2974898762 hasRelatedWork W2988003968 @default.
• W2974898762 hasRelatedWork W2993530583 @default.
• W2974898762 hasRelatedWork W3004652824 @default.
• W2974898762 hasRelatedWork W3007426674 @default.
• W2974898762 hasRelatedWork W3108314984 @default.
• W2974898762 hasRelatedWork W3119266832 @default.
• W2974898762 isParatext "false" @default.
• W2974898762 isRetracted "false" @default.
• W2974898762 magId "2974898762" @default.

• next