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- W2974903513 endingPage "133" @default.
- W2974903513 startingPage "133" @default.
- W2974903513 abstract "Anorexia nervosa (AN) affects 2.9 million people, many of whom experience bone loss and increased fracture risk. In this article, we review data on the underlying pathophysiology of AN-related osteoporosis and possible approaches to disease management. Available research suggests that low body weight and decreased gonadal function are the strongest predictors of bone loss and fractures in patients with AN. Additionally, other metabolic disturbances have been linked to bone loss, including growth hormone resistance, low leptin concentrations, and hypercortisolemia, but those correlations are less consistent and lack evidence of causality. In terms of treatment of AN-related bone disease, weight gain has the most robust impact on bone mineral density (BMD). Restoration of gonadal function seems to augment this effect and may independently improve BMD. Bisphosphonates, insulin-like growth factor 1 supplementation, and teriparatide may also be reasonable considerations, however need long-term efficacy and safety data." @default.
- W2974903513 created "2019-09-26" @default.
- W2974903513 creator A5002788021 @default.
- W2974903513 creator A5067688734 @default.
- W2974903513 date "2019-01-01" @default.
- W2974903513 modified "2023-09-27" @default.
- W2974903513 title "Anorexia Nervosa and Osteoporosis: Pathophysiology and Treatment" @default.
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- W2974903513 doi "https://doi.org/10.11005/jbm.2019.26.3.133" @default.
- W2974903513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6746661" @default.
- W2974903513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31555610" @default.
- W2974903513 hasPublicationYear "2019" @default.
- W2974903513 type Work @default.