FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2974922098> ?p ?o ?g. }

• W2974922098 endingPage "235" @default.
• W2974922098 startingPage "229" @default.
• W2974922098 abstract "Abstract Background In utero diaphragm development is critically important for postnatal respiratory function and any disturbance to fetal development may lead to diaphragm dysfunction and respiratory complications in the postnatal period. Intrauterine growth restriction (IUGR) has been shown to affect respiratory function in a sex‐dependent manner; however, the effect of IUGR on diaphragm function is unknown. Aim This study used a maternal hypoxia‐induced mouse model of IUGR to investigate the impact of IUGR on diaphragm function and structure in male and female adult offspring. Materials and Methods Pregnant BALB/c mice were housed under hypoxic conditions (10.5% O 2 ) from gestational days 11 to 17.5 and then returned to normoxic conditions. Control mice were housed under normoxic conditions throughout pregnancy. At 8 weeks of age, offspring were euthanized and diaphragms isolated for functional assessment in organ bath experiments and for histological analysis. Results IUGR offspring were lighter at birth and remained lighter at 8 weeks of age compared to Controls. While diaphragm force (maximal or twitch) was not affected by treatment or sex, the IUGR group exhibited a longer half‐relaxation time after twitch contractions compared to Control. Female offspring had a lower maximum rate of force development and higher fatigue resistance compared to males, independent of IUGR. There was no difference in the diaphragm myofibre cross‐sectional area between groups or sexes. Conclusion Sex and IUGR independently affect diaphragm contraction in adult mice without changes in structure. This study demonstrates that IUGR affects diaphragm contractile function in later life and could impair respiratory function if exacerbated under conditions of increased respiratory load." @default.
• W2974922098 created "2019-09-26" @default.
• W2974922098 creator A5006245077 @default.
• W2974922098 creator A5026173459 @default.
• W2974922098 creator A5037112434 @default.
• W2974922098 creator A5038179080 @default.
• W2974922098 date "2019-09-18" @default.
• W2974922098 modified "2023-10-16" @default.
• W2974922098 title "Intrauterine growth restriction affects diaphragm function in adult female and male mice" @default.
• W2974922098 cites W1588617135 @default.
• W2974922098 cites W178766069 @default.
• W2974922098 cites W1902806012 @default.
• W2974922098 cites W1969235931 @default.
• W2974922098 cites W1970022235 @default.
• W2974922098 cites W1982128010 @default.
• W2974922098 cites W1992377858 @default.
• W2974922098 cites W1995602286 @default.
• W2974922098 cites W1995909089 @default.
• W2974922098 cites W1999417131 @default.
• W2974922098 cites W2022028038 @default.
• W2974922098 cites W2027440191 @default.
• W2974922098 cites W2032998304 @default.
• W2974922098 cites W2043790950 @default.
• W2974922098 cites W2059697616 @default.
• W2974922098 cites W2061960683 @default.
• W2974922098 cites W2070097430 @default.
• W2974922098 cites W2076341585 @default.
• W2974922098 cites W2081673734 @default.
• W2974922098 cites W2081712911 @default.
• W2974922098 cites W2084282966 @default.
• W2974922098 cites W2094628201 @default.
• W2974922098 cites W2096759707 @default.
• W2974922098 cites W2097561994 @default.
• W2974922098 cites W2120114099 @default.
• W2974922098 cites W2132128408 @default.
• W2974922098 cites W2134259016 @default.
• W2974922098 cites W2135432484 @default.
• W2974922098 cites W2144495443 @default.
• W2974922098 cites W2151218235 @default.
• W2974922098 cites W2151392308 @default.
• W2974922098 cites W2152287187 @default.
• W2974922098 cites W2164778729 @default.
• W2974922098 cites W2167564898 @default.
• W2974922098 cites W2302484695 @default.
• W2974922098 cites W2397504889 @default.
• W2974922098 cites W2547082780 @default.
• W2974922098 cites W2615805232 @default.
• W2974922098 cites W2777780277 @default.
• W2974922098 doi "https://doi.org/10.1002/ppul.24519" @default.
• W2974922098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31535471" @default.
• W2974922098 hasPublicationYear "2019" @default.
• W2974922098 type Work @default.
• W2974922098 sameAs 2974922098 @default.
• W2974922098 citedByCount "5" @default.
• W2974922098 countsByYear W29749220982020 @default.
• W2974922098 countsByYear W29749220982021 @default.
• W2974922098 crossrefType "journal-article" @default.
• W2974922098 hasAuthorship W2974922098A5006245077 @default.
• W2974922098 hasAuthorship W2974922098A5026173459 @default.
• W2974922098 hasAuthorship W2974922098A5037112434 @default.
• W2974922098 hasAuthorship W2974922098A5038179080 @default.
• W2974922098 hasBestOaLocation W29749220982 @default.
• W2974922098 hasConcept C112672928 @default.
• W2974922098 hasConcept C121332964 @default.
• W2974922098 hasConcept C126322002 @default.
• W2974922098 hasConcept C134018914 @default.
• W2974922098 hasConcept C157138929 @default.
• W2974922098 hasConcept C164292776 @default.
• W2974922098 hasConcept C172680121 @default.
• W2974922098 hasConcept C201614185 @default.
• W2974922098 hasConcept C24890656 @default.
• W2974922098 hasConcept C2778376644 @default.
• W2974922098 hasConcept C2778780700 @default.
• W2974922098 hasConcept C2779234561 @default.
• W2974922098 hasConcept C42407357 @default.
• W2974922098 hasConcept C534529494 @default.
• W2974922098 hasConcept C54355233 @default.
• W2974922098 hasConcept C71924100 @default.
• W2974922098 hasConcept C86803240 @default.
• W2974922098 hasConceptScore W2974922098C112672928 @default.
• W2974922098 hasConceptScore W2974922098C121332964 @default.
• W2974922098 hasConceptScore W2974922098C126322002 @default.
• W2974922098 hasConceptScore W2974922098C134018914 @default.
• W2974922098 hasConceptScore W2974922098C157138929 @default.
• W2974922098 hasConceptScore W2974922098C164292776 @default.
• W2974922098 hasConceptScore W2974922098C172680121 @default.
• W2974922098 hasConceptScore W2974922098C201614185 @default.
• W2974922098 hasConceptScore W2974922098C24890656 @default.
• W2974922098 hasConceptScore W2974922098C2778376644 @default.
• W2974922098 hasConceptScore W2974922098C2778780700 @default.
• W2974922098 hasConceptScore W2974922098C2779234561 @default.
• W2974922098 hasConceptScore W2974922098C42407357 @default.
• W2974922098 hasConceptScore W2974922098C534529494 @default.
• W2974922098 hasConceptScore W2974922098C54355233 @default.
• W2974922098 hasConceptScore W2974922098C71924100 @default.
• W2974922098 hasConceptScore W2974922098C86803240 @default.
• W2974922098 hasFunder F4320323612 @default.
• W2974922098 hasFunder F4320334705 @default.

• next