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- W2974996878 abstract "Chemokines refer to chemoattractant cytokines, which have crucial functions in inflammation and immune responses in multiple cellular processes. In the present study, we described the potential role of porcine CCL5 in embryo implantation and fetal-maternal environment during early pregnancy. We first carried out phylogenetic analysis of porcine CCL5, and analyzed the cell specific localization of CCL5 and its receptor CCR3 in a kinetic approach within porcine estrous cycles and early gestation stage. In addition, CCL5 stimulated porcine uterine luminal epithelial (pLE) and porcine trophectoderm (pTr) cell proliferations, and cell cycle progressions via AKT and MAPK intracellular signaling tractions. Furthermore, CCL5 attenuated tunicamycin-induced endoplasmic reticulum (ER) stress signaling, and lipopolysaccharides-triggered inflammatory responses in pLE and pTr cells. Taken together, our study showed that CCL5 is involved in the placental development or promotes the placental development." @default.
- W2974996878 created "2019-10-03" @default.
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- W2974996878 date "2020-02-01" @default.
- W2974996878 modified "2023-10-01" @default.
- W2974996878 title "Function of CCL5 in maternal-fetal interface of pig during early pregnancy" @default.
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- W2974996878 doi "https://doi.org/10.1016/j.dci.2019.103503" @default.
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