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• W2975002841 abstract "To identify if static oxidation-reduction potential (sORP) can be used clinically at the time of insemination to predict low fertilisation. Multi-site prospective control blind study involving 6 independent clinics. Interim analysis assessing data from the first 10 patients enrolled in the study. Primary outcome for the interim analysis: rate of low fertilisation (<25% 2PN/MII), normal fertilisation (2PN per MII). Secondary outcomes: overall fertilisation rate (2+PN per MII), 1PN and 3PN rates per MII, daily embryo quality, morphokinetic parameters. Inclusion Criteria: patients undergoing IVF with at least 4 follicles ≥10mm, and 4 mature oocytes collected. While the semen sample was prepared for IVF treatment, 30ul was analysed using Mioxsys. Samples were divided into two groups based on the reading obtained from the Mioxsys, above and below a pre-established threshold. The scientists collecting data from the Mioxsys machine were not aware of the cut-off value to determine treatment, or the outcome of the treatment at the time of data entry. Embryos were cultured in the Embryoscope. Out of the first ten patients (134 mature oocytes), nine had normal sORP (0.12-0.93, 121 oocytes, Control), and one patient had high sORP (1.69, 13 oocytes, Treatment). Interestingly, the only patient with a low fertilisation rate (2/13, 20%) was in the Treatment group, whilst normal fertilisation rates were all normal in the Control group (ranging from 50-100%, overall 88/121=73%). Compared to Control, Treatment group had a lower 2PN rate (Control vs Treatment: 88/121=73% vs 2/13=15%, p<0.01), higher polyploidy rate (5/121=4% vs 5/13=38%, p<0.001). Difference in overall fertilisation rate approached significance (93/121=77% vs 7/13=54%, p=0.07). 1PN rate (7/121=6% vs 0/13, NS), median number of cells on day 2 (4 vs 3, NS) and day 3 (7 vs 6.5, NS), did not differ between Treatment and Control. Cleavage embryos with more day 3 fragmentation (sORP 0.66+- 0.37) or more unevenness (sORP 0.59+-0.36, n=49) were associated with higher sORP than embryos with lower day 3 fragmentation (sORP 0.25+-0.22 respectively, p<0.0001) or more evenness (sORP 0.38+-0.4, n=25, p=0.03). However, good embryo quality rate on days 2 (45/88 vs ½, NS), and 3 (32/74 vs ½, NS) did not differ between Treatment and Control. Morphokinetics was not significantly affected by treatment. Out of 10 patients undergoing IVF, sORP assessment correctly identified the 1 case where low fertilisation occurred. With 25% of normospermic samples leading to low fertilisation, new diagnostic tools are required to ascertain whether IVF is the correct treatment. This is the first multi-site prospective study assessing whether sORP can be used this way. Although preliminary, our results are encouraging and in line with other single-centre publications." @default.
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• W2975002841 date "2019-09-01" @default.
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• W2975002841 title "Multi-site, blind prospective trial assessing whether semen oxidation reduction potential (sORP) assessment can be used to predict low fertilisation with conventional IVF: interim analysis" @default.
• W2975002841 doi "https://doi.org/10.1016/j.fertnstert.2019.07.851" @default.
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