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- W2975151997 endingPage "1676" @default.
- W2975151997 startingPage "1676" @default.
- W2975151997 abstract "Small GTPases are organizers of a plethora of cellular processes. The time and place of their activation are tightly controlled by the localization and activation of their regulators, guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Remarkably, in some systems, the upstream regulators of GTPases are also found downstream of their activity. Resulting feedback loops can generate complex spatiotemporal dynamics of GTPases with important functional consequences. Here we discuss the concept of positive autoregulation of small GTPases by the GEF-effector feedback modules and survey recent developments in this exciting area of cell biology." @default.
- W2975151997 created "2019-10-03" @default.
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- W2975151997 date "2019-09-23" @default.
- W2975151997 modified "2023-10-15" @default.
- W2975151997 title "Autoactivation of small GTPases by the GEF–effector positive feedback modules" @default.
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- W2975151997 doi "https://doi.org/10.12688/f1000research.20003.1" @default.
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