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- W2975173656 abstract "Current adoptive T cell therapies conducted in an autologous setting are costly, time consuming, and depend on the quality of the patient's T cells. To address these issues, we developed a strategy in which cytotoxic T lymphocytes (CTLs) are regenerated from iPSCs that were originally derived from T cells and succeeded in regenerating CTLs specific for the WT1 antigen, which exhibited therapeutic efficacy in a xenograft model of leukemia. In this study, we extended our strategy to solid tumors. The regenerated WT1-specific CTLs had a strong therapeutic effect in orthotopic xenograft model using a renal cell carcinoma (RCC) cell line. To make our method more generally applicable, we developed an allogeneic approach by transducing HLA-haplotype homozygous iPSCs with WT1-specific TCR α/β genes that had been tested clinically. The regenerated CTLs antigen-specifically suppressed tumor growth in a patient-derived xenograft model of RCC, demonstrating the feasibility of our strategy against solid tumors." @default.
- W2975173656 created "2019-10-03" @default.
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- W2975173656 date "2019-10-01" @default.
- W2975173656 modified "2023-09-25" @default.
- W2975173656 title "SUB-PHENOTYPE ANALYSES OF BIPOLAR DISORDER IN DATA FROM THE PGC BIPOLAR DISORDER WORKING GROUP" @default.
- W2975173656 doi "https://doi.org/10.1016/j.euroneuro.2019.07.040" @default.
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