Matches in SemOpenAlex for { <https://semopenalex.org/work/W2975296542> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2975296542 abstract "Sickle cell anemia (SCA) is a blood condition that causes severe pain. One of the treatment for patients with SCA is hydroxyurea (HU), which reduces the pain clearly. Administration of HU cause DNA damage in white blood cell. The aim of research was to assess the effect of combination of iron chelating agents with HU on the DNA damage induced by using HU.Blood samples were collected from 120 people (60 males - 60 females) aged 10 to 40 years. The experimental groups were divided into five groups: Healthy, SCA patients who do not take any medications, SCA patients who are taking HU only, SCA patients who take iron-chelating agents and SCA patients who take HU medication with iron chelating agents.The percentage of damage to their DNA has been detected by the technique of the comet assay and the fluorescent microscope. The results give a significant decrease (P<0.000) in DNA damage in patients taking HU with iron chelating agents compared with patients taking HU only (1.32 ± 1.51 and 6.36 ± 2.36; respectively). Administration of iron chelation drugs with HU may have a great benefit in improving patients' health and avoiding the damage to DNA in the white blood cells due to HU. Also chemistry analysis were measure hematological parameter(White blood cell - differentials of white blood cells – Red blood cell – Hemoglobin )White blood cell significantly increased in the Chelation only and Chelation and Hydroxyurea groups relative to the positive group. Red blood cell counts, the patients who subjected to hydroxyurea and/or chelating agents have the least counts among all the groups. Furthermore, all treated groups when compared to the normal group have significantly reduced in red blood cell counts. Regarding the amounts of hemoglobin , all of the experimental groups significantly decreased relative to the normal group and Serum analysis( lactate dehydrogenase –Fetal hemoglobin–Transferrin receptor – Ferritin )The Fetal hemoglobin , Transferrin receptor and Ferritin levels in Chelation only and Chelation and Hydroxyurea groups were significantly greater than all of the other groups but decrease in lactate dehydrogenase in the same group ." @default.
- W2975296542 created "2019-10-03" @default.
- W2975296542 creator A5020811951 @default.
- W2975296542 date "2019-01-01" @default.
- W2975296542 modified "2023-09-24" @default.
- W2975296542 title "Effect of Combination of Hydroxyurea and Iron Chelation Therapy on DNA Damage in the Leukocytes of Sickle Cell Anemia Patients" @default.
- W2975296542 hasPublicationYear "2019" @default.
- W2975296542 type Work @default.
- W2975296542 sameAs 2975296542 @default.
- W2975296542 citedByCount "0" @default.
- W2975296542 crossrefType "journal-article" @default.
- W2975296542 hasAuthorship W2975296542A5020811951 @default.
- W2975296542 hasConcept C126322002 @default.
- W2975296542 hasConcept C143425029 @default.
- W2975296542 hasConcept C178790620 @default.
- W2975296542 hasConcept C185592680 @default.
- W2975296542 hasConcept C197404232 @default.
- W2975296542 hasConcept C203014093 @default.
- W2975296542 hasConcept C2776557347 @default.
- W2975296542 hasConcept C2777218474 @default.
- W2975296542 hasConcept C2777799968 @default.
- W2975296542 hasConcept C2778248108 @default.
- W2975296542 hasConcept C2778488018 @default.
- W2975296542 hasConcept C2778620579 @default.
- W2975296542 hasConcept C2778917026 @default.
- W2975296542 hasConcept C2779134260 @default.
- W2975296542 hasConcept C552990157 @default.
- W2975296542 hasConcept C55493867 @default.
- W2975296542 hasConcept C71924100 @default.
- W2975296542 hasConcept C90924648 @default.
- W2975296542 hasConcept C98274493 @default.
- W2975296542 hasConceptScore W2975296542C126322002 @default.
- W2975296542 hasConceptScore W2975296542C143425029 @default.
- W2975296542 hasConceptScore W2975296542C178790620 @default.
- W2975296542 hasConceptScore W2975296542C185592680 @default.
- W2975296542 hasConceptScore W2975296542C197404232 @default.
- W2975296542 hasConceptScore W2975296542C203014093 @default.
- W2975296542 hasConceptScore W2975296542C2776557347 @default.
- W2975296542 hasConceptScore W2975296542C2777218474 @default.
- W2975296542 hasConceptScore W2975296542C2777799968 @default.
- W2975296542 hasConceptScore W2975296542C2778248108 @default.
- W2975296542 hasConceptScore W2975296542C2778488018 @default.
- W2975296542 hasConceptScore W2975296542C2778620579 @default.
- W2975296542 hasConceptScore W2975296542C2778917026 @default.
- W2975296542 hasConceptScore W2975296542C2779134260 @default.
- W2975296542 hasConceptScore W2975296542C552990157 @default.
- W2975296542 hasConceptScore W2975296542C55493867 @default.
- W2975296542 hasConceptScore W2975296542C71924100 @default.
- W2975296542 hasConceptScore W2975296542C90924648 @default.
- W2975296542 hasConceptScore W2975296542C98274493 @default.
- W2975296542 hasLocation W29752965421 @default.
- W2975296542 hasOpenAccess W2975296542 @default.
- W2975296542 hasPrimaryLocation W29752965421 @default.
- W2975296542 hasRelatedWork W141467117 @default.
- W2975296542 hasRelatedWork W1902144990 @default.
- W2975296542 hasRelatedWork W1985011360 @default.
- W2975296542 hasRelatedWork W2013392029 @default.
- W2975296542 hasRelatedWork W2027887215 @default.
- W2975296542 hasRelatedWork W2034392565 @default.
- W2975296542 hasRelatedWork W2052457371 @default.
- W2975296542 hasRelatedWork W2065540401 @default.
- W2975296542 hasRelatedWork W2161933079 @default.
- W2975296542 hasRelatedWork W2189868078 @default.
- W2975296542 hasRelatedWork W2223284527 @default.
- W2975296542 hasRelatedWork W2323938126 @default.
- W2975296542 hasRelatedWork W2339459511 @default.
- W2975296542 hasRelatedWork W2433440883 @default.
- W2975296542 hasRelatedWork W2559927528 @default.
- W2975296542 hasRelatedWork W3093093377 @default.
- W2975296542 hasRelatedWork W3171669726 @default.
- W2975296542 hasRelatedWork W82691459 @default.
- W2975296542 hasRelatedWork W2739730991 @default.
- W2975296542 hasRelatedWork W2945215107 @default.
- W2975296542 isParatext "false" @default.
- W2975296542 isRetracted "false" @default.
- W2975296542 magId "2975296542" @default.
- W2975296542 workType "article" @default.