FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2975332605> ?p ?o ?g. }

• W2975332605 abstract "Spores are required for long-term survival of many organisms, including most fungi. For the majority of fatal human fungal pathogens, spore germination is the key process required to initiate vegetative growth and ultimately cause disease. Because germination is required for pathogenesis, the process could hold fungal-specific targets for new antifungal drug development. Compounds that inhibit germination could be developed into high efficacy, low-toxicity drugs for use in the prevention and/or treatment of fungal spore-mediated diseases. To identify drugs with the ability to inhibit pathogenic fungal spore germination, we developed a novel luciferase-based germination assay, using spores of the meningitis-causing yeast Cryptococcus. We screened the L1300 Selleck Library of FDA-approved drugs and identified 27 that inhibit germination. Of these, 22 inhibited both germination and yeast growth, and 21 have not been previously indicated for use in the treatment of fungal diseases. We quantitated the inhibition phenotypes of 10 specific germination/growth inhibitors in detail and tested one drug, the antiparasitic compound pentamidine, in our mouse intranasal model of cryptococcal infection. We discovered that pentamidine was effective at reducing lung fungal burdens when used in either prophylaxis (before infection) or treatment (after establishing an infection). Due to its efficacy in vivo and low intranasal toxicity, pentamidine is a lead candidate for repurposing for broader use as an antigerminant to prevent spore-mediated disease in immunocompromised patients. Not only does pentamidine provide an opportunity for prophylaxis against fungal spores, but it also provides proof of concept for targeting pathogenic spore germination for antifungal drug development." @default.
• W2975332605 created "2019-10-03" @default.
• W2975332605 creator A5026934226 @default.
• W2975332605 creator A5038492648 @default.
• W2975332605 creator A5051669356 @default.
• W2975332605 date "2019-12-01" @default.
• W2975332605 modified "2023-10-13" @default.
• W2975332605 title "Spore Germination as a Target for Antifungal Therapeutics" @default.
• W2975332605 cites W144463289 @default.
• W2975332605 cites W1691783204 @default.
• W2975332605 cites W1894318670 @default.
• W2975332605 cites W1909891465 @default.
• W2975332605 cites W1934048966 @default.
• W2975332605 cites W1963947711 @default.
• W2975332605 cites W1987060808 @default.
• W2975332605 cites W1987730034 @default.
• W2975332605 cites W1993290417 @default.
• W2975332605 cites W1997794034 @default.
• W2975332605 cites W2004503571 @default.
• W2975332605 cites W2050463570 @default.
• W2975332605 cites W2059140883 @default.
• W2975332605 cites W2059266231 @default.
• W2975332605 cites W2069869192 @default.
• W2975332605 cites W2107794472 @default.
• W2975332605 cites W2113245600 @default.
• W2975332605 cites W2125789219 @default.
• W2975332605 cites W2131944141 @default.
• W2975332605 cites W2134122507 @default.
• W2975332605 cites W2136651521 @default.
• W2975332605 cites W2154555730 @default.
• W2975332605 cites W2159623498 @default.
• W2975332605 cites W2170016182 @default.
• W2975332605 cites W2286580524 @default.
• W2975332605 cites W2309011052 @default.
• W2975332605 cites W2337303087 @default.
• W2975332605 cites W2339763729 @default.
• W2975332605 cites W2606235207 @default.
• W2975332605 cites W2624678362 @default.
• W2975332605 cites W2767031614 @default.
• W2975332605 cites W2769550507 @default.
• W2975332605 cites W2786435729 @default.
• W2975332605 cites W2804572516 @default.
• W2975332605 cites W2956137181 @default.
• W2975332605 cites W3025163304 @default.
• W2975332605 cites W4211092440 @default.
• W2975332605 cites W4235314184 @default.
• W2975332605 cites W4235450272 @default.
• W2975332605 doi "https://doi.org/10.1128/aac.00994-19" @default.
• W2975332605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6879269" @default.
• W2975332605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31570398" @default.
• W2975332605 hasPublicationYear "2019" @default.
• W2975332605 type Work @default.
• W2975332605 sameAs 2975332605 @default.
• W2975332605 citedByCount "18" @default.
• W2975332605 countsByYear W29753326052020 @default.
• W2975332605 countsByYear W29753326052021 @default.
• W2975332605 countsByYear W29753326052022 @default.
• W2975332605 countsByYear W29753326052023 @default.
• W2975332605 crossrefType "journal-article" @default.
• W2975332605 hasAuthorship W2975332605A5026934226 @default.
• W2975332605 hasAuthorship W2975332605A5038492648 @default.
• W2975332605 hasAuthorship W2975332605A5051669356 @default.
• W2975332605 hasBestOaLocation W29753326051 @default.
• W2975332605 hasConcept C100701293 @default.
• W2975332605 hasConcept C126322002 @default.
• W2975332605 hasConcept C174618031 @default.
• W2975332605 hasConcept C2777530519 @default.
• W2975332605 hasConcept C2777893358 @default.
• W2975332605 hasConcept C2777914695 @default.
• W2975332605 hasConcept C2993691816 @default.
• W2975332605 hasConcept C59822182 @default.
• W2975332605 hasConcept C71924100 @default.
• W2975332605 hasConcept C86803240 @default.
• W2975332605 hasConcept C89423630 @default.
• W2975332605 hasConcept C98274493 @default.
• W2975332605 hasConceptScore W2975332605C100701293 @default.
• W2975332605 hasConceptScore W2975332605C126322002 @default.
• W2975332605 hasConceptScore W2975332605C174618031 @default.
• W2975332605 hasConceptScore W2975332605C2777530519 @default.
• W2975332605 hasConceptScore W2975332605C2777893358 @default.
• W2975332605 hasConceptScore W2975332605C2777914695 @default.
• W2975332605 hasConceptScore W2975332605C2993691816 @default.
• W2975332605 hasConceptScore W2975332605C59822182 @default.
• W2975332605 hasConceptScore W2975332605C71924100 @default.
• W2975332605 hasConceptScore W2975332605C86803240 @default.
• W2975332605 hasConceptScore W2975332605C89423630 @default.
• W2975332605 hasConceptScore W2975332605C98274493 @default.
• W2975332605 hasFunder F4320306082 @default.
• W2975332605 hasFunder F4320309331 @default.
• W2975332605 hasFunder F4320337355 @default.
• W2975332605 hasIssue "12" @default.
• W2975332605 hasLocation W29753326051 @default.
• W2975332605 hasLocation W29753326052 @default.
• W2975332605 hasLocation W29753326053 @default.
• W2975332605 hasLocation W29753326054 @default.
• W2975332605 hasOpenAccess W2975332605 @default.
• W2975332605 hasPrimaryLocation W29753326051 @default.
• W2975332605 hasRelatedWork W2021231262 @default.
• W2975332605 hasRelatedWork W2249878239 @default.
• W2975332605 hasRelatedWork W2355629085 @default.

• next