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• W2975428341 abstract "<b><i>Background:</i></b> Perivascular adipose tissue (PVAT) reduces vascular tone in isolated arteries in vitro, however there are no studies of PVAT effects on vascular tone in vivo. In vitro adipocyte β₃-adrenoceptors play a role in PVAT function via secretion of the vasodilator adiponectin. <b><i>Objective:</i></b> We have investigated the effects of PVAT on vessel diameter in vivo, and the contributions of β₃-adrenoceptors and adiponectin. <b><i>Method:</i></b> In anaesthetised rats, sections of the intact mesenteric bed were visualised and the diameter of arteries was recorded. Arteries were stimulated with electrical field stimulation (EFS), noradrenaline (NA), arginine-vasopressin (AVP), and acetylcholine (Ach). <b><i>Results:</i></b> We report that in vivo, stimulation of PVAT with EFS, NA, and AVP evokes a local anti-constrictive effect on the artery, whilst PVAT exerts a pro-contractile effect on arteries subjected to Ach. The anti-constrictive effect of PVAT stimulated with EFS and NA was significantly reduced using β₃-adrenoceptor inhibition, and activation of β₃-adrenoceptors potentiated the anti-constrictive effect of vessels stimulated with EFS, NA, and AVP. The β₃-adrenoceptor agonist had no effect on mesenteric arteries with PVAT removed. A blocking peptide for adiponectin receptor 1 polyclonal antibody reduced the PVAT anti-constrictive effect in arteries stimulated with EFS and NA, indicating that adiponectin may be the anti-constrictive factor released upon β₃-adrenoceptor activation. <b><i>Conclusions:</i></b> These results clearly demonstrate that PVAT plays a paracrine role in regulating local vascular tone in vivo, and therefore may contribute to the modulation of blood pressure. This effect is mediated via adipocyte β₃-adrenoceptors, which may trigger release of the vasodilator adiponectin." @default.
• W2975428341 created "2019-10-03" @default.
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• W2975428341 date "2019-01-01" @default.
• W2975428341 modified "2023-10-12" @default.
• W2975428341 title "Perivascular Adipose Tissue Contributes to the Modulation of Vascular Tone in vivo" @default.
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• W2975428341 doi "https://doi.org/10.1159/000502689" @default.
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