FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2975446113> ?p ?o ?g. }

• W2975446113 endingPage "672" @default.
• W2975446113 startingPage "655" @default.
• W2975446113 abstract "Abstract Background Multiple circulatory factors are increased in heart failure (HF). Many have been linked to cardiac and/or skeletal muscle tissue processes, which in turn might influence physical activity and/or capacity during HF. This study aimed to provide a better understanding of the mechanisms linking HF with the loss of peripheral function. Methods and results Physical capacity measured by maximum oxygen uptake, myocardial function (measured by echocardiography), physical activity (measured by accelerometry), and mortality data was collected for patients with severe symptomatic heart failure an ejection fraction < 35% ( n = 66) and controls ( n = 28). Plasma circulatory factors were quantified using a multiplex immunoassay. Multivariate (orthogonal projections to latent structures discriminant analysis) and univariate analyses identified many factors that differed significantly between HF and control subjects, mainly involving biological functions related to cell growth and cell adhesion, extracellular matrix organization, angiogenesis, and inflammation. Then, using principal component analysis, links between circulatory factors and physical capacity, daily physical activity, and myocardial function were identified. A subset of ten biomarkers differentially expressed in patients with HF vs controls covaried with physical capacity, daily physical activity, and myocardial function; eight of these also carried prognostic value. These included established plasma biomarkers of HF, such as NT-proBNP and ST2 along with recently identified factors such as GDF15, IGFBP7, and TfR, as well as a new factor, galectin-4. Conclusions These findings reinforce the importance of systemic circulatory factors linked to hemodynamic stress responses and inflammation in the pathogenesis and progress of HF disease. They also support established biomarkers for HF and suggest new plausible markers. Graphic abstract" @default.
• W2975446113 created "2019-10-03" @default.
• W2975446113 creator A5001978233 @default.
• W2975446113 creator A5006756969 @default.
• W2975446113 creator A5024467832 @default.
• W2975446113 creator A5039308014 @default.
• W2975446113 creator A5044599590 @default.
• W2975446113 creator A5048551894 @default.
• W2975446113 date "2019-09-27" @default.
• W2975446113 modified "2023-10-16" @default.
• W2975446113 title "Circulatory factors associated with function and prognosis in patients with severe heart failure" @default.
• W2975446113 cites W106420479 @default.
• W2975446113 cites W1535592737 @default.
• W2975446113 cites W1852955086 @default.
• W2975446113 cites W1963854726 @default.
• W2975446113 cites W1964270363 @default.
• W2975446113 cites W1968114517 @default.
• W2975446113 cites W1975913194 @default.
• W2975446113 cites W1978604479 @default.
• W2975446113 cites W1981130287 @default.
• W2975446113 cites W1986563731 @default.
• W2975446113 cites W1992039515 @default.
• W2975446113 cites W1992162714 @default.
• W2975446113 cites W2000112570 @default.
• W2975446113 cites W2000731251 @default.
• W2975446113 cites W2001662646 @default.
• W2975446113 cites W2001984572 @default.
• W2975446113 cites W2003935940 @default.
• W2975446113 cites W2004557419 @default.
• W2975446113 cites W2006538101 @default.
• W2975446113 cites W2007937185 @default.
• W2975446113 cites W2010084870 @default.
• W2975446113 cites W2012072620 @default.
• W2975446113 cites W2015384362 @default.
• W2975446113 cites W2022708342 @default.
• W2975446113 cites W2039689324 @default.
• W2975446113 cites W2041031177 @default.
• W2975446113 cites W2049455741 @default.
• W2975446113 cites W2061538346 @default.
• W2975446113 cites W2063166582 @default.
• W2975446113 cites W2066913822 @default.
• W2975446113 cites W2067288051 @default.
• W2975446113 cites W2071101151 @default.
• W2975446113 cites W2079132293 @default.
• W2975446113 cites W2084745706 @default.
• W2975446113 cites W2085051928 @default.
• W2975446113 cites W2087407895 @default.
• W2975446113 cites W2087708034 @default.
• W2975446113 cites W2089027985 @default.
• W2975446113 cites W2089468765 @default.
• W2975446113 cites W2089634605 @default.
• W2975446113 cites W2090629102 @default.
• W2975446113 cites W2090678743 @default.
• W2975446113 cites W2091677016 @default.
• W2975446113 cites W2099610554 @default.
• W2975446113 cites W2103679597 @default.
• W2975446113 cites W2108488321 @default.
• W2975446113 cites W2111038476 @default.
• W2975446113 cites W2111180872 @default.
• W2975446113 cites W2114599876 @default.
• W2975446113 cites W2115452947 @default.
• W2975446113 cites W2119340816 @default.
• W2975446113 cites W2121184422 @default.
• W2975446113 cites W2121339038 @default.
• W2975446113 cites W2124018534 @default.
• W2975446113 cites W2125597090 @default.
• W2975446113 cites W2127920599 @default.
• W2975446113 cites W2136174372 @default.
• W2975446113 cites W2143814414 @default.
• W2975446113 cites W2145179900 @default.
• W2975446113 cites W2152264817 @default.
• W2975446113 cites W2159675211 @default.
• W2975446113 cites W2162758488 @default.
• W2975446113 cites W2170798597 @default.
• W2975446113 cites W2170939072 @default.
• W2975446113 cites W2171055760 @default.
• W2975446113 cites W2235603523 @default.
• W2975446113 cites W2239599130 @default.
• W2975446113 cites W2270010895 @default.
• W2975446113 cites W2297418668 @default.
• W2975446113 cites W2311196768 @default.
• W2975446113 cites W2325656490 @default.
• W2975446113 cites W2339046060 @default.
• W2975446113 cites W2341820027 @default.
• W2975446113 cites W2342019990 @default.
• W2975446113 cites W2529406298 @default.
• W2975446113 cites W2538460872 @default.
• W2975446113 cites W2583611799 @default.
• W2975446113 cites W2609744794 @default.
• W2975446113 cites W2620648363 @default.
• W2975446113 cites W2889352094 @default.
• W2975446113 cites W2911628245 @default.
• W2975446113 cites W37880063 @default.
• W2975446113 cites W4205457333 @default.
• W2975446113 cites W4230731944 @default.
• W2975446113 cites W4293860347 @default.
• W2975446113 doi "https://doi.org/10.1007/s00392-019-01554-3" @default.
• W2975446113 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7239817" @default.

• next