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• W2975446719 abstract "Parabens are a group of alkyl esters of p-hydroxybenzoic acid that are widely used as preservatives in personal care products, cosmetics, pharmaceuticals, and food processing. While parabens have shown weak estrogenic effects in animal models, epidemiologic studies of their health effects are limited. There have been no studies of the association between paraben exposure and UL incidence. We evaluated the association between urinary concentrations of parabens and incidence of uterine leiomyomata (UL). Case-cohort analysis nested within the Study of Environment, Lifestyle and Fibroids (SELF), a prospective cohort study of 1,693 Black women aged 23-35 from Detroit, MI. After enrollment in 2010-2012, women were followed with telephone-assisted interviews, self-administered questionnaires, and in-person office visits that involved standardized ultrasound examinations and first-morning urine sample collection at baseline, 20 months, 40 months, and 60 months of follow-up. The CDC measured urinary concentrations of ethylparaben (EP), methylparaben (MP) and propylparaben (PP) using liquid chromatography with tandem mass spectrometry. UL were ascertained using ultrasound. Among the UL-free subcohort randomly-selected at baseline and all incident UL cases (N=765 women, including 298 cases), we estimated rate ratios (RR) and 95% confidence intervals (CI) using age-stratified Cox regression adjusted for age at menarche, smoking, alcohol, BMI, education, reproductive history, and current hormonal contraceptive use. We found detectable concentrations of EP, MP, and PP in the baseline urine of 79%, 100%, and 100% of participants, respectively, with median concentrations of 2.34, 115, and 16.6 μg/g creatinine. Individual paraben concentrations were weakly to moderately correlated across time points, with Spearman correlations (r) ranging from as low as 0.23 for PP (baseline vs. 40 months) to as high as 0.43 for MP (20 vs. 40 months). MP and PP concentrations were highly correlated with each other (r: 0.76-0.80), but other pairs of parabens were not. RRs comparing highest vs. lowest quartiles of cumulatively-averaged (i.e., baseline, 20 and 40 month samples) creatinine-adjusted concentrations of EP, MP, and PP were 0.90 (CI: 0.65-1.24), 0.72 (CI: 0.51-1.02), and 0.66 (CI: 0.46-0.93), respectively, but no dose-response associations were observed. For the total molar sum of all parabens, RRs comparing quartiles 2, 3, and 4 (highest) vs. 1 (lowest) of cumulatively-averaged creatinine-adjusted concentrations were 0.85 (CI: 0.61-1.17), 0.87 (CI: 0.63-1.21), and 0.65 (CI: 0.46-0.93), respectively. Models using baseline urinary concentrations produced comparable findings. Results were similar across strata of BMI and parity, but were attenuated among current users of hormonal contraception. Among reproductive-aged Black women, urinary concentrations of selected parabens were weakly inversely associated with UL incidence." @default.
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• W2975446719 date "2019-09-01" @default.
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• W2975446719 title "Urinary paraben concentrations and incidence of uterine leiomyomata: a prospective ultrasound study" @default.
• W2975446719 doi "https://doi.org/10.1016/j.fertnstert.2019.07.346" @default.
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